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Related Concept Videos

Redox Reactions01:27

Redox Reactions

Redox reactions are vital biochemical processes that underpin energy metabolism in cells. These reactions involve the transfer of electrons between molecules, occurring in tandem as oxidation and reduction. Oxidation refers to the loss of electrons, while reduction denotes their gain. This coupling ensures the seamless flow of electrons through metabolic pathways. For example, in bacterial metabolism, glucose undergoes oxidation to carbon dioxide, while oxygen is simultaneously reduced to...
Redox Reactions01:24

Redox Reactions

Oxidation-reduction or redox reactions involve the transfer of electrons from one molecule or atom to another. When an atom gains an electron, another atom must lose an electron, meaning oxidation and reduction must occur together. Since the redox occurs in pairs, the atom that gets oxidized is also called the reducing agent or reductant, and the atom that is reduced is also called the oxidizing agent or oxidant. A straightforward way to remember the definitions of oxidation and reduction is...
Redox Equilibria: Overview01:23

Redox Equilibria: Overview

A reduction-oxidation reaction is commonly called a redox reaction. In a redox reaction, electrons are transferred from one species to another rather than being shared between or among atoms. The reducing agent or reductant is the species that loses electrons and gets oxidized in the process. The species that gains electrons and gets reduced in the process is the oxidizing agent or oxidant. Redox reactions are represented as two separate equations called half-reactions, where one equation...
Redox Titration: Overview01:21

Redox Titration: Overview

Redox titration is a chemical analysis technique used to determine the concentration of an unknown substance by measuring the electron transfer in a redox (reduction-oxidation) reaction. The process involves gradually adding a titrant with a known concentration of an oxidizing or reducing agent, to the analyte, the solution with an unknown concentration, until reaching the endpoint, which indicates the completion of the reaction between the two substances. Ensuring the analyte is in a single...
Redox Titration: Other Oxidizing and Reducing Agents01:26

Redox Titration: Other Oxidizing and Reducing Agents

Besides iodine, other oxidizing or reducing agents can serve as titrants in redox titrations. Common oxidizing titrants include KMnO4, cerium(IV), and K2Cr2O7. The choice of oxidizing titrants depends on factors like stability, cost, analyte strength, and reaction rate between the analyte and titrant. KMnO4 is a strong oxidizing titrant that reduces from Mn(VII) to Mn(II) in a highly acidic solution, simultaneously oxidizing the analyte to a higher oxidation state. In this case, KMnO4 acts as a...
Oxidation and Reduction of Organic Molecules01:19

Oxidation and Reduction of Organic Molecules

Energy production within a cell involves many coordinated chemical pathways. Most of these pathways are combinations of oxidation and reduction reactions, which occur at the same time. An oxidation reaction strips an electron from an atom in a compound, and the addition of this electron to another compound is a reduction reaction. Because oxidation and reduction usually occur together, these pairs of reactions are called redox reactions.
The removal of an electron from a molecule, results in a...

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Related Experiment Video

Updated: May 9, 2026

Resin-Assisted Capture Coupled with Isobaric Tandem Mass Tag Labeling for Multiplexed Quantification of Protein Thiol Oxidation
07:16

Resin-Assisted Capture Coupled with Isobaric Tandem Mass Tag Labeling for Multiplexed Quantification of Protein Thiol Oxidation

Published on: June 21, 2021

The redox proteome.

Young-Mi Go1, Dean P Jones

  • 1From the Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, Georgia 30322.

The Journal of Biological Chemistry
|July 18, 2013
PubMed
Summary
This summary is machine-generated.

The redox proteome, involving protein modifications, regulates biological functions and adaptability to environmental factors. Understanding these redox-active chemical interactions is key to cellular health and response.

Keywords:
GlutathioneRedox RegulationSystems BiologyThiolThioredoxin

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Related Experiment Videos

Last Updated: May 9, 2026

Resin-Assisted Capture Coupled with Isobaric Tandem Mass Tag Labeling for Multiplexed Quantification of Protein Thiol Oxidation
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Published on: June 21, 2021

Profiling Thiol Redox Proteome Using Isotope Tagging Mass Spectrometry
12:07

Profiling Thiol Redox Proteome Using Isotope Tagging Mass Spectrometry

Published on: March 24, 2012

Cellular Redox Profiling Using High-content Microscopy
11:37

Cellular Redox Profiling Using High-content Microscopy

Published on: May 14, 2017

Area of Science:

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Background:

  • The redox proteome encompasses reversible and irreversible covalent modifications.
  • These modifications link redox metabolism to biological structure and function.
  • Cysteine residues are key sites for redox modifications.

Purpose of the Study:

  • To elucidate the role of redox proteome modifications in biological processes.
  • To understand the impact of redox-active chemicals on cellular functions.
  • To explore the connection between redox proteome and adaptability to environmental challenges.

Main Methods:

  • Analysis of protein modifications.
  • Investigation of redox-active chemical interactions.
  • Assessment of cellular responses to environmental factors.

Main Results:

  • Redox modifications, particularly on cysteine, are crucial for protein folding, catalysis, signaling, and cellular structure.
  • Interactions with redox-active chemicals influence macromolecular structure, regulation, and signaling throughout the life cycle.
  • The redox proteome plays a vital role in tolerance and adaptation to dietary and environmental challenges.

Conclusions:

  • The redox proteome is a critical regulator of cellular processes and adaptation.
  • Understanding redox modifications provides insights into health and disease.
  • Targeting redox pathways may offer strategies for enhancing resilience to environmental stressors.