Related Experiment Video
Updated: May 9, 2026
Characterization of Vascular Morphology of Neovascular Age-Related Macular Degeneration by Indocyanine Green Angiography
Published on: August 11, 2023
Lymphocyte infiltration in CAPN5 autosomal dominant neovascular inflammatory vitreoretinopathy
Vinit B Mahajan1, Jonathan H Lin
1Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA ; Omics Laboratory, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
Purpose:
To describe immunohistopathological findings in autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV).
Methods:
An enucleated eye specimen from a patient with Stage V ADNIV was examined using standard histopathological methods and lymphocyte markers.
Results:
A c.731T>C CAPN5 mutation resulted in a p.Leu244Pro substitution in calpain-5. The eye showed exudative retinal detachment and neovascularization, intraocular fibrosis, and features of phthisis bulbi. Chronic inflammatory CD3-positive cell infiltrates were identified throughout the uvea, vitreous and retina, consistent with chronic uveitis.
Conclusion:
Mutations in CAPN5 trigger autoimmune uveitis characterized by inflammatory T-cells and severe neovascularization.
