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Related Concept Videos

Vaccinations01:51

Vaccinations

Overview
Cross-reactivity00:42

Cross-reactivity

Overview
Immunological Memory01:23

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...

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Related Experiment Video

Updated: May 9, 2026

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

Herpes zoster vaccination.

Kyung Hoon Kim1

  • 1Department of Anesthesia and Pain Medicine, School of Medicine, Pusan National University, Yangsan, Korea.

The Korean Journal of Pain
|July 18, 2013
PubMed
Summary
This summary is machine-generated.

Varicella zoster virus (VZV) vaccination reduces shingles (herpes zoster) occurrence and pain duration in adults over 50. However, its efficacy in preventing recurrent shingles or reducing postherpetic neuralgia severity is not proven.

Keywords:
chickenpoxherpes zosterherpes zoster vaccinehuman herpesvirus 3postherpetic neuralgia

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Area of Science:

  • Virology
  • Immunology
  • Dermatology

Background:

  • Varicella zoster virus (VZV) causes chickenpox and can reactivate as shingles (herpes zoster).
  • Shingles can lead to persistent pain, known as postherpetic neuralgia (PHN).
  • VZV vaccination aims to prevent VZV reactivation and subsequent HZ and PHN.

Purpose of the Study:

  • To evaluate the efficacy of VZV vaccination in preventing shingles and postherpetic neuralgia.
  • To assess the impact of vaccination on the duration and severity of shingles-related pain.
  • To identify adverse reactions associated with VZV vaccination.

Main Methods:

  • Clinical studies involving vaccination with an attenuated VZV form.
  • Assessment of VZV reactivation, HZ occurrence, pain duration, and PHN frequency.
  • Monitoring of adverse events in vaccinated individuals.

Main Results:

  • Vaccination reduced HZ occurrence by 50-70% and decreased HZ pain duration in individuals aged ≥ 50 years.
  • The vaccine did not demonstrate efficacy in preventing recurrent HZ episodes or reducing PHN severity.
  • Long-term efficacy of the vaccine remains undetermined.

Conclusions:

  • VZV vaccination is effective in reducing the incidence and pain duration of shingles in older adults.
  • Further research is needed to establish the vaccine's efficacy against recurrent HZ and severe PHN.
  • Common adverse reactions include injection site pain and headache; contraindications apply to specific populations.