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Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Male Sexual Response: Erection & Ejaculation01:17

Male Sexual Response: Erection & Ejaculation

Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors01:28

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
Penis01:29

Penis

The penis serves a dual role in sexual reproduction and urination. It consists of three main regions: the glans penis, the body, and the root, each with distinct functions and unique anatomical features.
Anatomy of the Penis
The glans penis, or the head, is the terminal part of the penis and houses the external urethral orifice, the exit point for urine and semen. Covered by the prepuce, or foreskin, the glans is noted for its sensitivity and plays a key role in sexual pleasure. The body of the...
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations01:26

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...

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Related Experiment Video

Updated: May 9, 2026

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
05:25

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Published on: August 14, 2019

[Benign prostatic hyperplasia and erectile dysfunction: an update].

Yu Fan1

  • 1Department of Andrology, Mianyang Central Hospital, Mianyang, Sichuan 821000, China. fanyu68@yahoo.com.cn

Zhonghua Nan Ke Xue = National Journal of Andrology
|July 19, 2013
PubMed
Summary
This summary is machine-generated.

Benign prostatic hyperplasia (BPH) and erectile dysfunction (ED) are linked, with potential shared causes like nitric oxide changes. Screening for ED in BPH patients is recommended, and PDE5 inhibitors may help treat BPH symptoms.

Related Experiment Videos

Last Updated: May 9, 2026

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
05:25

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Published on: August 14, 2019

Area of Science:

  • Urology
  • Andrology
  • Men's Health

Context:

  • Epidemiological studies reveal a significant correlation between benign prostatic hyperplasia (BPH) and erectile dysfunction (ED).
  • This association persists irrespective of patient age or comorbidities such as diabetes.
  • The underlying pathophysiological mechanisms linking BPH and ED are multifactorial.

Purpose:

  • To explore the correlation between benign prostatic hyperplasia (BPH) and erectile dysfunction (ED).
  • To identify potential pathophysiological factors contributing to the BPH-ED link.
  • To recommend clinical screening and evaluate potential therapeutic strategies.

Summary:

  • Shared pathophysiological factors may include altered nitric oxide bioavailability, increased autonomic activity, alpha-1 adrenergic receptor hyperactivity, RhoA/Rho-kinase pathway imbalance, and metabolic syndrome.
  • Clinical practice should incorporate screening for sexual dysfunction in men presenting with BPH.
  • Phosphodiesterase type 5 (PDE5) inhibitors demonstrate potential for managing lower urinary tract symptoms associated with BPH.

Impact:

  • Highlights the clinical importance of assessing sexual function in BPH patients.
  • Suggests PDE5 inhibitors as a potential therapeutic option for BPH-related lower urinary tract symptoms.
  • Underscores the need for further research into preventative strategies and novel therapies for both conditions.