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Updated: May 9, 2026

Measurement of Insulin- and Contraction-Stimulated Glucose Uptake in Isolated and Incubated Mature Skeletal Muscle from Mice
Published on: May 16, 2021
[Involvement of Akt in regulation of skeletal muscle metabolism]
Abstract:
The enzyme Akt 1 is a member of serine/threonine specific protein kinases family. Akt plays an important role in the transmission of extracellular signals and mechanical stimuli via phosphorylation of its numerous substrates involved in anabolic and catabolic processes as well as mechanical responses of skeletal muscle. Expression of the Akt is increased during skeletal muscle hypertrophy and decreased during muscle atrophy. The G205T polymorphism of Akt is associated with transcriptional activity of the gene in muscle cells and, respectively, with skeletal muscle phenotypes.
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