Related Experiment Video
Updated: May 9, 2026

Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced In Vitro Model
Published on: December 2, 2022
Polydatin: a review of pharmacology and pharmacokinetics
Qiao-Hui Du1, Cheng Peng, Hong Zhang
1Key Laboratory of Standardization of Chinese Herbal Medicines of Ministry of Education, Chengdu University of Traditional Chinese Medicine, Pharmacy College , Chengdu , P.R. China and.
Context:
Polydatin, also named piceid (3,4',5-trihydroxystilbene-3-β-d-glucoside, PD), is a monocrystalline compound isolated from Polygonum cuspidatum Sieb. et Zucc. (Polygonaceae), but is also detected in grape, peanut, hop cones, red wines, hop pellets, cocoa-containing products, chocolate products and many daily diets. There are numerous investigations reported of PD in the past 22 years, but they are usually scattered across various publications, which may block further research and clinical use of PD.
Objective:
The article summarizes and evaluates the published scientific information of PD pharmacological effects and pharmacokinetics since 1990.
Materials And Methods:
The information from 98 cases included in this review was compiled using major databases such as MEDLINE, Elsevier, Springer, PubMed, Scholar and CNKI.
Results:
Numerous pharmacological investigations of PD mainly focus on cardiovascular effects, neuroprotection, anti-inflammatory and immunoregulatory effects, anti-oxidation, anti-tumor, liver and lung protection, etc.
Conclusion:
A great number of pharmacological and pharmacokinetic investigations in the past 22 years have demonstrated that PD has favorable therapeutic properties, indicating its potential as an effective material. However, further research is needed to explore its molecular mechanisms of action and definitive target proteins.
Related Concept Videos
Pharmacodynamics: Overview and Principles
Most drugs' effects result from their interactions with drug receptors or targets within the body. These interactions trigger specific responses at the cellular or systemic level. Drug receptors can be found on the surfaces of cells or within...
Pharmacokinetic–Pharmacodynamic Relationship: Problems
Pharmacokinetic–Pharmacodynamic Relationship: Duration of Dose-Effect Relationship
Dosage Regimens: Partial Pharmacokinetic Parameters
Pharmacodynamic Responses: Different Types
Protein-Drug Binding: Mechanism and Kinetics
Various forces drive these interactions, including hydrogen bonds, hydrophobic interactions, ionic bonds, electrostatic interactions, and van der Waals forces. These bonds enable drugs to bind to specific sites on proteins,...

