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Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Delivering flavonoids into solid tumors using nanotechnologies.

Shengpeng Wang1, Jinming Zhang, Meiwan Chen

  • 1Assistant Professor, University of Macau, Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine , Av. Padre Tomas Pereira S.J, Taipa, Macau, 999078 , China mwchen@umac.mo.

Expert Opinion on Drug Delivery
|July 19, 2013
PubMed
Summary
This summary is machine-generated.

Dietary flavonoids show promise in cancer prevention, but poor bioavailability limits effectiveness. Nanotechnology offers a solution for delivering these compounds, like quercetin and EGCG, to tumors, enhancing their anticancer potential.

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Area of Science:

  • Oncology
  • Pharmacology
  • Nanotechnology

Background:

  • Epidemiological studies link dietary flavonoids to reduced chronic disease and cancer risk.
  • Poor bioavailability of flavonoids limits their therapeutic efficacy in clinical settings.
  • Nanotechnology is emerging as a strategy to enhance flavonoid delivery to tumor sites.

Purpose of the Study:

  • To review the benefits of flavonoids in cancer therapy.
  • To discuss factors influencing flavonoid bioavailability.
  • To explore nanotechnology-based delivery systems for flavonoids like quercetin, EGCG, and genistein.

Main Methods:

  • Literature review on flavonoid benefits and bioavailability.
  • Focus on nanotechnology approaches for quercetin, epigallocatechin-3-gallate (EGCG), and genistein.
  • Summary of challenges and potential of flavonoid delivery systems.

Main Results:

  • Nanotechnology significantly improves the delivery and bioavailability of flavonoids.
  • Targeted delivery systems enhance the anticancer efficacy of flavonoids.
  • Further research is needed to optimize flavonoid delivery systems.

Conclusions:

  • Developing effective molecular carriers for flavonoids is crucial.
  • Many promising flavonoids are hindered by poor in vivo parameters.
  • Clinical trials are essential to evaluate the efficacy and safety of novel flavonoid delivery systems.