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Related Experiment Video

Updated: May 9, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

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Gliosarcoma with ependymal and PNET-like differentiation.

Masayuki Shintaku, Hiroyuki Yoneda, Junko Hirato

    Clinical Neuropathology
    |July 19, 2013
    PubMed
    Summary

    This study reports a rare temporal lobe gliosarcoma with diverse glial differentiation, including ependymal and primitive neuroectodermal tumor (PNET)-like components. The findings suggest a primitive neuroepithelial origin and potential involvement of epithelial-mesenchymal transition (EMT) in its development.

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    Area of Science:

    • Neuro-oncology
    • Molecular pathology
    • Cancer biology

    Background:

    • Gliosarcoma is a rare malignant brain tumor.
    • Understanding its diverse differentiation is crucial for diagnosis and treatment.
    • This case presents unique features not previously reported.

    Observation:

    • A rare gliosarcoma occurred in the temporal lobe of a 39-year-old male.
    • The gliomatous component showed ependymal differentiation and a primitive neuroectodermal tumor (PNET)-like area.
    • The mesenchymal component displayed atypical spindle cells with transcription factors involved in epithelial-mesenchymal transition (EMT).

    Findings:

    • The PNET-like component expressed markers like synaptophysin and CD99, but not glial markers (GFAP).
    • The mesenchymal cells were immunoreactive for Slug and Twist, suggesting EMT involvement.

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  • This is the first reported case of gliosarcoma with glial differentiation towards both ependymal and PNET-like elements.

    • Implications:

    • The diverse differentiation suggests origin from primitive neuroepithelial progenitor cells.
    • Epithelial-mesenchymal transition (EMT) may play a role in the pathogenesis of this rare gliosarcoma.
    • Further research into the molecular mechanisms of gliosarcoma with diverse differentiation is warranted.