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Platelets and matrix metalloproteinases

P Seizer1, A E May

  • 1Peter Seizer, Medizinische Klinik III, Universitätsklinikum Tübingen, Otfried Müller-Str.10, 72076 Tübingen, Germany, Tel.: +49 7071 29 83160; Fax: +49 7071 29 4473,

Thrombosis and Haemostasis
|July 19, 2013
PubMed

Insights

Platelets significantly influence disease by regulating matrix metalloproteinases (MMPs) and their inhibitors. This review explores platelet-derived and induced MMPs in various pathophysiologies.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Pathophysiology

Background:

  • Matrix metalloproteinases (MMPs) and their inhibitors are crucial in disease processes like inflammation and tissue degradation.
  • Platelets play a significant role in modulating MMP activity within these pathophysiologies.

Purpose of the Study:

  • This review focuses on the multifaceted roles of platelet-associated matrix metalloproteinases (MMPs) and their inhibitors.
  • To elucidate the mechanisms by which platelets influence MMP activity and contribute to disease.

Main Methods:

  • Literature review of studies investigating MMPs and platelets in various pathological conditions.
  • Analysis of mechanisms including leukocyte recruitment, paracrine signaling, and direct synthesis of MMPs by platelets.

Main Results:

  • Platelets concentrate leukocyte-derived MMPs at injury sites.
  • Platelets stimulate MMP production in other cells via receptor interactions and paracrine signaling.
  • Platelets synthesize and secrete MMP-1, MMP-2, MMP-3, MMP-14, and potentially MMP-9, along with tissue inhibitors of metalloproteinase (TIMPs).

Conclusions:

  • Platelet-derived and platelet-induced MMPs are key players in diverse pathophysiologies.
  • Understanding these platelet-MMP interactions is vital for developing therapeutic strategies targeting vascular injury, inflammation, and cancer.
Keywords:
EMMPRINMMPPlatelets

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