Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Assembly of Complex Microtubule Structures01:32

Assembly of Complex Microtubule Structures

Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
Microtubule Instability02:17

Microtubule Instability

Microtubules are hollow cylindrical filaments having a diameter of approximately 25 nm and a length that varies from 200 nm to 25 μm. GTP-bound tubulin subunits form αβ-heterodimers for microtubule assembly. These core building blocks interact longitudinally, polymerizing into protofilaments. The protofilaments then interact with one another through lateral bonding forces to form stable cylindrical microtubules. These cylindrical filaments are dynamic as they undergo repeated assembly and...
Microtubule Formation01:23

Microtubule Formation

Microtubules are dynamic structures that undergo continuous assembly and disassembly. They originate from specialized multi-protein complexes known as microtubule organizing centers or MTOCs. Within the MTOC, the point of origin of the microtubule is known as the minus end, while the end radiating outward is the plus end. Microtubules serve two primary functions — the organization of spindle complexes to separate sister chromatids during mitotic or meiotic cell division and the formation of...
Destabilization of Microtubules01:45

Destabilization of Microtubules

The destabilization of microtubules can occur during different stages of the microtubule lifecycle, such as nucleation or elongation. It can take place at either end of the microtubule or in the microtubule lattices as a whole. The lifespan of individual microtubules within a cell varies according to the cell type and stage of the cell cycle. During interphase, the lifespan of the microtubule is about 30 minutes, while during cell division, it is about 15 minutes. In axonal microtubules of...
Microtubules in Cell Motility01:24

Microtubules in Cell Motility

Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form cellular appendages like cilia and flagella, which are responsible for locomotion. The cilia arise from basal bodies, separated from the main body by a membrane-like structure forming the transition zone. This zone is the gate for the entry of lipids and proteins, creating a unique composition of lipids and proteins in the ciliary membrane and...
Microtubules in Cell Motility01:24

Microtubules in Cell Motility

Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form cellular appendages like cilia and flagella, which are responsible for locomotion. The cilia arise from basal bodies, separated from the main body by a membrane-like structure forming the transition zone. This zone is the gate for the entry of lipids and proteins, creating a unique composition of lipids and proteins in the ciliary membrane and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Possible involvement of the mesenchymal cell marker Meflin in regeneration after retinal injury.

Scientific reports·2026
Same author

Multimodal Imaging in Indolent Nonprogressive Multifocal Choroidal Lesions: A Case Report.

Cureus·2026
Same author

Multiple Evanescent White Dot Syndrome After mRNA COVID-19 Vaccination.

Cureus·2026
Same author

Increased Meflin Expression in Cancer-Associated Fibroblasts Restrains Tumor Cell Proliferation and Shapes Vessel-Rich Stroma in Triple-Negative Breast Cancer.

The American journal of pathology·2026
Same author

Feasibility of a Smart Label-Enabled Remote Therapeutic Monitoring Intervention to Support Cyclin-Dependent Kinase 4/6 Inhibitor Adherence in Breast Cancer Care.

JCO clinical cancer informatics·2025
Same author

Meflin/ISLR is a meningeal cell-specific marker involved in the development of meninges and meningioma progression.

Brain pathology (Zurich, Switzerland)·2025
Same journal

Deep learning in tumour genomics: from multi-omics integration to precision oncology.

Open biology·2026
Same journal

Understanding GnRH: local systems, signalling mechanisms and implications in female health.

Open biology·2026
Same journal

The evolution and functional significance of neuropeptide cocktails: insights from SALMFamides in asteroid echinoderms.

Open biology·2026
Same journal

Structural basis of Drosophila insulin receptor activation by DILP2 hormone.

Open biology·2026
Same journal

Parental rearing shapes brain functional networks and socio-sexual behaviours in the prairie vole.

Open biology·2026
Same journal

The periosteum as an endocrine organ: historical foundations and new insights.

Open biology·2026
See all related articles

Related Experiment Video

Updated: May 9, 2026

High-resolution Time-lapse Imaging and Automated Analysis of Microtubule Dynamics in Living Human Umbilical Vein Endothelial Cells
10:25

High-resolution Time-lapse Imaging and Automated Analysis of Microtubule Dynamics in Living Human Umbilical Vein Endothelial Cells

Published on: August 13, 2016

Microtubule dynamics in neuronal morphogenesis.

Akira Sakakibara1, Ryota Ando, Tamar Sapir

  • 1Department of Anatomy and Cell Biology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan. a.sakaki@med.nagoya-u.ac.jp

Open Biology
|July 19, 2013
PubMed
Summary
This summary is machine-generated.

Microtubules (MTs) are crucial for developing brain cells. Live imaging reveals how MT organization and centrosome positioning dynamically shape neurons during development.

Keywords:
axoncentrosomemicrotubulesmigrationneuronpolarity

More Related Videos

In vivo Assessment of Microtubule Dynamics and Orientation in Caenorhabditis elegans Neurons
07:43

In vivo Assessment of Microtubule Dynamics and Orientation in Caenorhabditis elegans Neurons

Published on: November 20, 2021

Related Experiment Videos

Last Updated: May 9, 2026

High-resolution Time-lapse Imaging and Automated Analysis of Microtubule Dynamics in Living Human Umbilical Vein Endothelial Cells
10:25

High-resolution Time-lapse Imaging and Automated Analysis of Microtubule Dynamics in Living Human Umbilical Vein Endothelial Cells

Published on: August 13, 2016

In vivo Assessment of Microtubule Dynamics and Orientation in Caenorhabditis elegans Neurons
07:43

In vivo Assessment of Microtubule Dynamics and Orientation in Caenorhabditis elegans Neurons

Published on: November 20, 2021

Area of Science:

  • Neuroscience
  • Cell Biology
  • Developmental Biology

Background:

  • Microtubules (MTs) are vital for neuronal structure and function.
  • MT-based motors are critical for cell division and process formation.
  • Neuronal development relies on regulated MT stability and organization.

Purpose of the Study:

  • To review recent advances in live imaging techniques.
  • To explore the dynamics of MT organization during neural development.
  • To understand the role of centrosome positioning in neuronal MT organization.

Main Methods:

  • Live imaging microscopy
  • Analysis of microtubule dynamics
  • Studies on centrosome positioning

Main Results:

  • Live imaging provides new insights into MT dynamics.
  • Centrosome positioning is a key factor in neuronal MT organization.
  • Axons and dendrites show distinct MT organization patterns.

Conclusions:

  • Dynamic MT organization and centrosome positioning are essential for neural development.
  • Understanding these processes is key to comprehending neuronal morphogenesis.
  • Recent live imaging advances have significantly improved our knowledge in this field.