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Related Experiment Video

Updated: May 9, 2026

Characterizing Multidrug Efflux Systems in Acinetobacter baumannii Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System

Characterizing Multidrug Efflux Systems in Acinetobacter baumannii Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System

Published on: January 5, 2024

[Multi-drug resistant bacteria, a complex mechanism].

Jean-Christophe Hilaire¹

¹Cadre de Santé infirmier Hygiéniste, Service de Prévention du risque infectieux, Centre hospitalier de Versailles, France. jchilaire@ch-versailles.fr

Revue De L'Infirmiere

|July 20, 2013

Summary

This summary is machine-generated.

Multidrug-resistant bacteria are a growing concern, showing resistance to many antibiotics. This issue emerged in hospitals shortly after the introduction of antibiotics, with Staphylococcus strains developing penicillin resistance in the 1960s.

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Expression, Detergent Solubilization, and Purification of a Membrane Transporter, the MexB Multidrug Resistance Protein

Expression, Detergent Solubilization, and Purification of a Membrane Transporter, the MexB Multidrug Resistance Protein

Published on: December 3, 2010

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Last Updated: May 9, 2026

Characterizing Multidrug Efflux Systems in Acinetobacter baumannii Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System

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Expression, Detergent Solubilization, and Purification of a Membrane Transporter, the MexB Multidrug Resistance Protein

Expression, Detergent Solubilization, and Purification of a Membrane Transporter, the MexB Multidrug Resistance Protein

Published on: December 3, 2010

Area of Science:

Microbiology
Infectious Diseases

Context:

The emergence of multidrug resistance (MDR) in bacteria poses a significant threat to public health.
Antibiotic resistance has been observed since the early days of antibiotic use, highlighting a long-standing challenge in medicine.

Purpose:

To define multidrug resistance in bacterial pathogens.
To provide historical context on the onset of antibiotic resistance.

Summary:

Bacteria are classified as multidrug-resistant when they exhibit sensitivity to only a limited range of available antibiotic treatments.
The phenomenon of antibiotic resistance was documented in clinical settings soon after the advent of antibiotic therapies.
A notable early instance includes the development of penicillin resistance in Staphylococcus strains during the 1960s.

Impact:

Understanding the historical trajectory of antibiotic resistance is crucial for developing effective future treatment strategies.
Highlights the persistent and evolving nature of bacterial resistance to antimicrobial agents.