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Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
Solid lipid dispersions: potential delivery system for functional ingredients in foods
Aboagyewa Asumadu-Mensah1, Kevin W Smith, Henelyta S Ribeiro
1School of Biosciences, Univ. of Nottingham, UK.
Journal of Food Science
|July 20, 2013
Summary
High-melting structured solid lipid (SL) systems were produced using stearic acid, candelilla wax, and carnauba wax. These SL dispersions exhibited controlled particle sizes and unique morphologies, demonstrating potential for advanced carrier systems.
Area of Science:
- Materials Science
- Pharmaceutical Technology
Background:
- Structured solid lipid (SL) systems offer enhanced physical stability and controlled release.
- High-melting point lipids are explored for novel SL carrier system development.
Purpose of the Study:
- Investigate the use of high-melting point SLs for structured carrier systems.
- Evaluate the impact of lipid type and oil inclusion on particle characteristics.
Main Methods:
- Hot melt high-pressure homogenization to produce SL and SL+oil dispersions.
- Static light scattering for particle size analysis.
- Transmission electron microscopy (TEM) for morphology assessment.
- Differential scanning calorimetry (DSC) for crystallization behavior analysis.
Main Results:
- Particle sizes varied with lipid type: stearic acid (195 nm), candelilla wax (178 nm), and carnauba wax (303 nm).
- Inclusion of sunflower oil generally reduced particle size.
- TEM revealed plate-like and needle-like particle morphologies.
- DSC showed lower melting and crystallization temperatures for SL dispersions compared to bulk lipids.
Conclusions:
- High-melting SLs are suitable for creating structured carrier systems.
- Particle size, morphology, and thermal properties are influenced by lipid composition and processing.
- The observed thermal behavior is attributed to small particle size, high surface area, and surfactant presence.
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