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Updated: May 9, 2026

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Published on: March 28, 2017
Cytochrome P450 2J2: distribution, function, regulation, genetic polymorphisms and clinical significance
Meijuan Xu1, Wenzheng Ju, Haiping Hao
1State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Cytochrome P450 2J2 (CYP2J2) is an enzyme involved in drug metabolism and cardiovascular health. Its role in cancer development and drug interactions highlights the need for further research into its functions and potential therapeutic applications.
Area of Science:
- Biochemistry
- Pharmacology
- Molecular Biology
Background:
- Cytochrome P450 2J2 (CYP2J2) is predominantly expressed in extrahepatic tissues, particularly the cardiovascular system.
- CYP2J2 exhibits epoxygenase activity, metabolizing arachidonic acid (AA) into epoxyeicosatrienoic acids (EETs) with significant biological effects.
- Recent findings indicate high CYP2J2 expression in human tumors, suggesting its involvement in cancer pathology.
Purpose of the Study:
- To review the multifaceted roles of CYP2J2 in cardiovascular systems, cancer development, and xenobiotic metabolism.
- To explore the substrates, regulation, genetic variations, and inhibitors of CYP2J2.
- To emphasize the need for continued investigation into CYP2J2's implications in disease and clinical practice.
Main Methods:
- Literature review of studies on CYP2J2 expression, activity, and function.
- Analysis of research on CYP2J2's role in arachidonic acid metabolism and cancer.
- Examination of studies concerning CYP2J2's involvement in drug metabolism and its regulation.
Main Results:
- CYP2J2 metabolizes arachidonic acid to biologically active EETs, impacting cardiovascular function.
- CYP2J2 is implicated in the pathological development of various human cancers.
- CYP2J2 acts as a Phase I xenobiotic metabolizer for structurally diverse compounds, including antihistamines.
- CYP2J2 expression is not readily induced but can be regulated by pathological conditions, AP-1, and microRNA let-7b.
- Genetic mutations in CYP2J2 have been identified and may be associated with certain diseases.
Conclusions:
- CYP2J2 plays a critical role in cardiovascular health and disease, as well as in cancer progression.
- Understanding CYP2J2's substrate specificity and metabolic pathways is crucial for drug development.
- Further research is essential to fully elucidate CYP2J2's functions in disease pathology, drug development, and clinical applications.
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