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Circadian Rhythms and Gene Regulation

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...

Circadian Rhythms and Gene Regulation

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...

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Related Experiment Video

Updated: May 9, 2026

In Vivo Monitoring of Circadian Clock Gene Expression in the Mouse Suprachiasmatic Nucleus Using Fluorescence Reporters

In Vivo Monitoring of Circadian Clock Gene Expression in the Mouse Suprachiasmatic Nucleus Using Fluorescence Reporters

Published on: July 4, 2018

Circadian Disruption: comparing humans with mice.

Leora C Radetsky¹, Mark S Rea, Andrew Bierman

¹Lighting Research Center, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.

Chronobiology International

|July 20, 2013

Summary

Disrupting the 24-hour light-dark cycle, common in shiftwork, causes circadian disruption. This study found similar circadian disruption patterns in nurses and mice, suggesting a useful method for health outcome studies.

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Last Updated: May 9, 2026

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Published on: July 4, 2018

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System

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Published on: December 16, 2022

Area of Science:

Chronobiology
Endocrinology
Occupational Health

Background:

Disruption of the 24-hour light-dark cycle is an endocrine disruptor linked to adverse health outcomes.
Shiftwork, particularly rotating shifts, significantly impacts circadian rhythms.
Previous studies indicated circadian disruption in shift-working nurses.

Purpose of the Study:

To compare circadian disruption levels in humans (nurses) and mice exposed to simulated shiftwork light-dark patterns.
To evaluate the utility of phasor analysis in quantifying circadian entrainment across species.
To bridge ecological human studies with parametric animal models for health outcome research.

Main Methods:

Collected and analyzed circadian disruption data from day-shift and rotating-shift nurses.
Simulated shiftwork light-dark patterns in mice.
Utilized phasor analysis to measure circadian entrainment (phasor magnitude) in both humans and mice.

Main Results:

Phasor magnitudes, indicating circadian entrainment, were comparable between humans and mice under similar light-dark cycle disruptions.
The study demonstrated a quantitative similarity in circadian disruption patterns across species.
Phasor analysis proved effective in measuring circadian disruption.

Conclusions:

Phasor analysis provides a quantitative method to compare circadian disruption across different species.
This method can link human occupational health studies with animal model research.
Findings support the use of mouse models to study health outcomes related to circadian disruption from shiftwork.