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Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy
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Posterior reversible encephalopathy syndrome.

Rohana Naqi1, Muhammad Azeemuddin

  • 1Department of Radiology, Dow University of Health Sciences, Karachi. rohana.naqi@gmail.com

JPMA. the Journal of the Pakistan Medical Association
|July 23, 2013
PubMed
Summary
This summary is machine-generated.

Posterior Reversible Encephalopathy Syndrome (PRES) often presents with varied imaging findings, primarily vasogenic edema in the parietal and occipital lobes. Prompt diagnosis and treatment lead to clinical improvement and neuroimaging recovery within weeks.

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Area of Science:

  • Neurology
  • Radiology
  • Neuroimaging

Background:

  • Posterior Reversible Encephalopathy Syndrome (PRES) is a neurological condition characterized by a distinct set of clinical and neuroimaging findings.
  • Understanding the diverse presentations of PRES is crucial for accurate and timely diagnosis.

Purpose of the Study:

  • To evaluate the Magnetic Resonance Imaging (MRI) features in patients diagnosed with Posterior Reversible Encephalopathy Syndrome (PRES).
  • To correlate imaging findings with clinical outcomes and recovery patterns in PRES patients.

Main Methods:

  • A retrospective analysis of 12 patients with confirmed PRES between June 2005 and July 2009.
  • Review of standard MRI sequences including FLAIR, T1-weighted, T2-weighted, diffusion-weighted, and contrast-enhanced T1-weighted imaging.
  • Two blinded neuro-radiologists assessed imaging findings and involved regions.

Main Results:

  • T2-weighted hyperintense signals, indicative of vasogenic edema, were most commonly observed in the parietal or occipital regions (41.6%).
  • Other affected areas included deep white matter (25%), frontal lobes, inferior temporal lobes, cerebellar hemispheres, and basal ganglia (8.3% each).
  • Follow-up imaging (5-7 weeks) demonstrated marked clinical and radiological improvement, with complete resolution in some cases.

Conclusions:

  • Diverse clinical and radiographic presentations of PRES necessitate heightened awareness to prevent misdiagnosis and treatment delays.
  • PRES is a reversible condition with prompt management, typically resulting in good patient outcomes.
  • This series confirms significant clinical improvement and recovery in most PRES patients within weeks of treatment initiation.