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Updated: May 9, 2026
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Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording
Published on: September 1, 2022
A coaxial optrode as multifunction write-read probe for optogenetic studies in non-human primates
Ilker Ozden1, Jing Wang, Yao Lu
1School of Engineering, Brown University, Providence, RI, USA. ilker_ozden@brown.edu
Journal of Neuroscience Methods
|July 23, 2013
Summary
A new coaxial optrode enables precise light delivery, electrophysiology, and fluorescence detection in non-human primate (NHP) brains. This innovation minimizes brain trauma for advanced optogenetic research and potential therapeutics.
Area of Science:
- Neuroscience
- Biomedical Engineering
- Optogenetics
Background:
- Optogenetics shows promise in non-human primates (NHPs) but lacks compatible multifunction optoelectronic probes.
- Existing probes hinder precision light delivery, electrophysiology, fluorescence detection, and cause significant brain trauma.
Purpose of the Study:
- To develop a novel brain probe for simultaneous optogenetics and electrophysiology in NHPs.
- To overcome limitations of existing probes for NHP brain research and therapeutic translation.
Main Methods:
- A coaxial optrode was microfabricated with a tapered, gold-coated optical fiber in a polyamide tube.
- The device integrates precision light delivery, electrophysiology, and fluorescence detection with minimal tissue damage.
Main Results:
- The coaxial optrode demonstrated effective performance in rodents and NHPs.
- It enabled precise optical stimulation, electrophysiology, and opsin expression mapping with minimal cortical damage.
Conclusions:
- The coaxial optrode is a key tool for studying light-modulated neural activity and behavior in NHPs.
- Its design supports future chronic implantation and multisite neural recording applications.
