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Related Concept Videos

Cells and Secretions of the Pancreas01:16

Cells and Secretions of the Pancreas

The pancreas, a vital organ within the abdominal cavity, plays dual roles in the digestive and endocrine systems, collaborating with exocrine and endocrine cells to maintain optimal digestion and blood sugar levels.
Exocrine function is carried out by acinar cells, organized into clusters known as acini. These cells contribute to digestion by releasing substantial quantities of enzyme-rich, alkaline digestive juices.
Concurrently, the dispersed clusters of endocrine cells throughout the...
Pancreas01:19

Pancreas

The pancreas, an essential organ in the human body, is a pinkish-gray elongated structure located posterior to the stomach. It extends laterally from the duodenum towards the spleen and is firmly bound to the posterior wall of the abdominal cavity. The organ's surface has a lumpy, lobular texture that gives it a unique appearance.
The broad head of the pancreas lies within the loop formed by the duodenum, while its slender body reaches towards the spleen. The tail of the pancreas is short and...

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Related Experiment Video

Updated: May 9, 2026

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice
10:43

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice

Published on: October 31, 2007

The plastic pancreas.

Oren Ziv1, Benjamin Glaser, Yuval Dor

  • 1Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.

Developmental Cell
|July 23, 2013
PubMed
Summary
This summary is machine-generated.

Pancreas cells can regenerate and change identity, offering new insights into diabetes and pancreatic cancer. This suggests a dynamic organ capable of repair and adaptation under stress.

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Related Experiment Videos

Last Updated: May 9, 2026

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice
10:43

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice

Published on: October 31, 2007

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Published on: March 15, 2024

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Area of Science:

  • Cell biology
  • Endocrinology
  • Regenerative medicine

Background:

  • Pancreas homeostasis relies on differentiated cell replication.
  • Acinar cells may act as facultative progenitors after injury.
  • Endocrine cells can alter identity under metabolic stress or genetic mutation.

Purpose of the Study:

  • To explore the dynamic nature of pancreas cell populations.
  • To investigate the potential for pancreas regeneration.
  • To link pancreas cell plasticity to disease.

Main Methods:

  • Review of recent studies on pancreas cell dynamics.
  • Analysis of cellular responses to injury and metabolic stress.
  • Exploration of progenitor cell capabilities.

Main Results:

  • Acinar cells show potential for dedifferentiation into multipotent progenitors.
  • Hormone-producing endocrine cells can change or lose identity.
  • Pancreas cell plasticity is linked to regeneration and disease.

Conclusions:

  • The pancreas exhibits greater cellular plasticity than previously thought.
  • This plasticity connects pancreas regeneration to pathologies like diabetes and cancer.
  • Understanding these dynamics could inform therapeutic strategies.