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Hepatic menin recruits SIRT1 to control liver steatosis through histone deacetylation

Yanan Cao1, Ying Xue, Lu Xue

  • 1Department of Endocrinology and Metabolism, Shanghai Clinical Center for Endocrine and Metabolic Diseases and Shanghai Institute of Endocrinology and Metabolism, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, 197 Rui-Jin 2nd Road, Shanghai 200025, China.

Journal of Hepatology
|July 23, 2013
PubMed
Abstract

Insights

Menin deficiency worsens liver steatosis in aging and high-fat diet-fed mice. This adaptor protein is crucial for regulating hepatic lipid accumulation and may offer therapeutic targets for non-alcoholic fatty liver disease.

Area of Science:

  • Hepatology
  • Molecular Biology
  • Metabolic Diseases

Background:

  • Non-alcoholic fatty liver disease (NAFLD) is linked to aging, obesity, and type 2 diabetes.
  • Understanding NAFLD regulatory networks is key for developing new treatments.

Purpose of the Study:

  • To investigate the role of the Multiple Endocrine Neoplasia 1 (Men1) gene and its encoded protein, menin, in liver steatosis.
  • To elucidate the mechanisms by which menin influences lipid metabolism in hepatocytes.

Main Methods:

  • Generated hepatocyte-specific Men1 knockout mice using Cre/loxP technology.
  • Assessed lipid and glucose metabolic phenotypes in aging and high-fat diet-fed mice.

Main Results:

  • Menin expression decreases in aging mouse livers.
  • Hepatocyte-specific Men1 deletion exacerbates liver steatosis in aging mice.
  • Menin deficiency promotes high-fat diet-induced liver steatosis by recruiting SIRT1 to regulate hepatic CD36 expression and triglyceride accumulation via histone deacetylation.

Conclusions:

  • The adaptor protein menin is essential for the progression of hepatic steatosis.
  • Menin plays a critical role in metabolic imbalance and liver fat accumulation during aging.
Keywords:
AgingHFDHistone deacetylationIPGTTITTLMKOLiver steatosisMEN1MeninNAFLDSIRT1Scd-1TCTGhigh-fat dietinsulin tolerance testsintra-peritoneal glucose tolerance testsliver-specific Men1 knockout micemultiple endocrine neoplasia type 1non-alcoholic fatty liver diseasestearoyl CoA desaturase-1total cholesteroltriglyceride

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