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MRI and PET in Mouse Models of Myocardial Infarction
10:46

MRI and PET in Mouse Models of Myocardial Infarction

Published on: December 19, 2013

Quantitative myocardial perfusion imaging by cardiovascular magnetic resonance and positron emission tomography

K Bratis1, I Mahmoud, A Chiribiri

  • 1Division of Imaging Sciences and Biomedical Engineering, King's College London, 4th Floor, Lambeth Wing, St. Thomas' Hospital, Westminster Bridge Road, London, SE1 7EH, United Kingdom, konstantinos.bratis@kcl.ac.uk.

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
|July 23, 2013
PubMed

Insights

Quantifying myocardial perfusion reserve (MPR) using non-invasive stress imaging, like positron emission tomography (PET) and cardiac magnetic resonance (CMR), helps assess coronary artery disease (CAD) risk. This review compares PET and CMR for accurate MPR quantification.

Area of Science:

  • Cardiovascular Imaging
  • Nuclear Cardiology
  • Cardiovascular Magnetic Resonance

Background:

  • Clinical management of coronary artery disease (CAD) increasingly focuses on identifying myocardial ischemia and quantifying ischemic burden, rather than solely relying on angiographic extent.
  • Non-invasive stress imaging techniques are preferred for assessing ischemia and guiding clinical decisions in patients with CAD.
  • Quantitative assessment of regional myocardial perfusion provides objective estimates of myocardial injury and infarction risk.

Purpose of the Study:

  • To review the evidence for using Positron Emission Tomography (PET) and Cardiac Magnetic Resonance (CMR) in quantifying myocardial perfusion reserve (MPR).
  • To highlight studies that directly compare the diagnostic performance of PET and CMR for MPR quantification.
  • To emphasize the role of MPR in assessing myocardial ischemia and guiding patient management.

Main Methods:

  • Review of current literature on PET and CMR for myocardial blood flow (MBF) and MPR quantification.
  • Focus on studies comparing PET and CMR methodologies for MPR assessment.
  • Inclusion of data on diagnostic performance and prognostic value of both imaging modalities.

Main Results:

  • PET is established as the reference standard for quantitative MBF and MPR.
  • CMR is increasingly utilized for MBF and MPR measurement using first-pass signals, demonstrating significant diagnostic performance and prognostic value.
  • Direct comparative studies between PET and CMR for MPR quantification are crucial for understanding their relative strengths.

Conclusions:

  • Non-invasive quantitative assessment of MPR using PET and CMR is vital for managing patients with CAD.
  • Both PET and CMR offer valuable insights into myocardial ischemia, aiding in risk stratification and clinical decision-making.
  • Further direct comparative studies are needed to fully elucidate the complementary roles and differences between PET and CMR in MPR quantification.

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