[Modulating effect of estradiol on the sensitivity of the preoptic area neurons to noradrenaline]

Sensitivity of the preoptic area neurons to norepinephrine before and after application of estradiol was investigated. The obtained results show that estradiol influences neuron sensitivity. Microiontophoretic application of norepinephrine followed the estradiol into the preoptic area and increased the activity of single neurons in the majority of experiments. This modulation effect of estradiol was more pronounced at the stage of proestrus.