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Updated: May 9, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Palladium-catalyzed regioselective synthesis of 2(2'-biphenyl)benzimidazoles through C-H activation
Li-Hsun Chen1, Tz-Yi Wu, Vijaykumar Paike
1Laboratory of Combinatorial Drug Design, Department of Applied Chemistry, National Chiao Tung University, Hsin-chu, 300-10, Taiwan.
Abstract:
An efficient palladium-catalyzed strategy through C-H bond activation for the synthesis of 2(2[Formula: see text]-biphenyl)-benzimidazoles is reported herein. The regioselective C-C bond formation proceeds in a sealed tube via oxidative C-H activation of ortho-directed 2-aryl-benzimidazole to couple with various iodobenzene analogs in high yields. This arylation exhibited high regioselectivity which is able to increase molecular diversity in difficult functionalized positions of parent molecules. This strategy provides a convenient and simple synthesis of biphenyl heterocyclic compounds with high regioselectivity.
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