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Related Experiment Videos

A portable microprocessor-based triggering device for cardiac muscle electrical stimulation.

J W Bassani1, E T Costa, M Rocha-e-Silva

  • 1Departamento de Engenharia Biomédica, Faculdade de Engenharia Elétrica, Universidade Estadual de Campinas, SP, Brasil.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
|January 1, 1990
PubMed
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A new programmable instrument controls electrical heart muscle stimulation patterns. Stimulus sequences did not alter tissue tension when stimulation frequency remained constant.

Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Neuroscience

Background:

  • Cardiac inotropism is influenced by electrical stimulation patterns.
  • Precise control over stimulus timing is crucial for studying cardiac electrophysiology.
  • Existing methods may lack flexibility in programming complex stimulation sequences.

Purpose of the Study:

  • To introduce a microprocessor-based instrument for programmable electrical stimulation of cardiac tissue.
  • To investigate the inotropic effects of different irregular stimulus sequences on isolated rat left atria.
  • To assess the instrument's utility in cardiac research and other biological preparations.

Main Methods:

  • Development of a microprocessor-based triggering instrument with non-volatile memory.

Related Experiment Videos

  • Programming stimulus sequences using a 25-command repertory.
  • Application of irregular electrical stimuli to isolated rat left atrial preparations at controlled frequencies (2 and 5 Hz).

    • Main Results:

    • The developed instrument successfully controlled the temporal distribution of electrical stimuli.
    • Mean peak tension in rat left atria was independent of stimulus sequence at maintained frequencies.
    • Consistent cardiac inotropic responses were observed despite variations in stimulus patterns.

    Conclusions:

    • The programmable triggering instrument offers precise control for cardiac electrophysiology studies.
    • Stimulus sequence does not significantly impact cardiac inotropism if mean frequency is constant.
    • This instrument is a valuable tool for investigating various biological preparations requiring controlled electrical stimulation.