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Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion

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Hyperglycaemia in patients treated with second generation antipsychotics.

R Mahendran¹, M M Hendricks

¹National University Health System; MM Hendricks, Institute of Mental Health/Woodbridge Hospital, Singapore. medrm@nus.edu.sg

La Clinica Terapeutica

|July 23, 2013

Summary

Second-generation antipsychotics are linked to hyperglycemia in Asian patients with schizophrenia or schizoaffective disorder. This study found a one-third prevalence, highlighting the need for careful monitoring.

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Improving IV Insulin Administration in a Community Hospital

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Published on: June 11, 2012

Area of Science:

Endocrinology
Psychiatry
Pharmacology

Background:

Second-generation antipsychotics (SGAs) are associated with hyperglycemia in Caucasian populations.
Asian populations have a higher predisposition to diabetes, making SGA-induced hyperglycemia a significant concern.
The impact of SGAs on glucose metabolism in Asian patients with schizophrenia or schizoaffective disorder is largely unknown.

Purpose of the Study:

To investigate the association between second-generation antipsychotics (SGAs) and hyperglycemia in Asian patients diagnosed with schizophrenia or schizoaffective disorder.
To assess the prevalence and timing of hyperglycemia onset in this patient group.
To inform clinical practice regarding glucose monitoring for Asian patients initiating SGAs.

Main Methods:

A health quality improvement project tracked 266 patients newly started on SGAs over two years.
Fasting plasma glucose levels were monitored at baseline, 4 weeks, 12 weeks, and 12 months.
Patients with pre-existing diabetes were excluded from the analysis.

Main Results:

Hyperglycemia was identified in 88 out of 252 eligible patients (34.9%).
The majority of hyperglycemia cases (77.3%) were observed at the 12-week follow-up.
Fasting plasma glucose levels peaked at the 4-week mark.

Conclusions:

A significant one-third prevalence of hyperglycemia was observed in Asian patients newly initiated on SGAs.
These findings underscore the need for proactive glucose monitoring and further research in this vulnerable population.
The study highlights potential risks associated with SGAs in Asian patients predisposed to diabetes.