Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antidepressant Drugs: MAOIs and Other Agents

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...

Psychosis: Goals of Pharmacotherapy

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...

Drug Therapy

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...

Psychosis and Antipsychotic Drugs: Overview

Psychosis and Antipsychotic Drugs: Overview

The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic symptoms in all...

Electroconvulsive Therapy

Electroconvulsive Therapy

Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early years,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Feasibility and safety of ALPPS procedure: our experience.

Surgical endoscopy·2025

Same author

Active breaks: a strategy to counteract sedentary behaviors for Health Promoting Schools. A discussion on their implementation in Italy.

Annali di igiene : medicina preventiva e di comunita·2022

Same author

Cerebral cortical thickness and gyrification changes in first-episode psychoses and multi-episode schizophrenia.

Archives italiennes de biologie·2021

Same author

Ultrashort high energy electron bunches from tunable surface plasma waves driven with laser wavefront rotation.

Physical review. E·2021

Same author

Oxygen-ozone therapy as adjuvant in the current emergency in SARS-COV-2 infection: a clinical study.

Journal of biological regulators and homeostatic agents·2020

Same author

The proteasome as a druggable target with multiple therapeutic potentialities: Cutting and non-cutting edges.

Pharmacology & therapeutics·2020

Search research articles

Related Experiment Video

Updated: May 9, 2026

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

[Phenelzine: legacy or current psychiatric practice?].

S Marini¹, D Serata, R Brugnoli

¹Didactic-Scientific Board of Master on Clinical Trials, School of Medicine and Psychology, Sapienza University of Rome, Italy.

La Clinica Terapeutica

|July 23, 2013

Summary

This summary is machine-generated.

Phenelzine, a monoamine oxidase inhibitor (MAOI), is reviewed for its efficacy and safety in treating mood and anxiety disorders. This analysis synthesizes clinical pharmacology and trial data to guide therapeutic use.

More Related Videos

Development of a Virtual Reality Assessment of Everyday Living Skills

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

Related Experiment Videos

Last Updated: May 9, 2026

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

Development of a Virtual Reality Assessment of Everyday Living Skills

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

Area of Science:

Psychopharmacology
Neuroscience
Clinical Psychiatry

Context:

Monoamine oxidase inhibitors (MAOIs) represent the earliest class of antidepressants.
Phenelzine is a widely used MAOI for various mood and anxiety disorders.
Understanding MAOI efficacy and safety is crucial for effective psychiatric treatment.

Purpose:

To critically review the international scientific literature on phenelzine's efficacy and safety.
To enhance understanding of the interplay between phenelzine's pharmacology, clinical application, and adverse effects.
To synthesize data from clinical pharmacology and controlled/uncontrolled studies.

Summary:

A comprehensive literature search (PubMed, 1980-2012) focused on phenelzine's clinical pharmacology and use in psychiatric disorders.
Findings are presented separately, detailing pharmacological properties and results from various clinical studies.
The review aims to clarify the relationship between phenelzine's drug profile and its clinical outcomes.

Impact:

Provides a consolidated overview of phenelzine's therapeutic profile.
Aids clinicians in optimizing phenelzine treatment strategies.
Contributes to informed decision-making regarding MAOI therapy in psychiatric practice.