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Patient-specific Modeling of the Heart: Estimation of Ventricular Fiber Orientations
12:09

Patient-specific Modeling of the Heart: Estimation of Ventricular Fiber Orientations

Published on: January 8, 2013

Modeling the dispersion in electromechanically coupled myocardium.

Thomas S E Eriksson1, Anton J Prassl, Gernot Plank

  • 1Institute of Biomechanics, Center of Biomedical Engineering, Graz University of Technology, 8010 Graz, Austria; Department of Biophysics, Medical University of Graz, 8010 Graz, Austria.

International Journal for Numerical Methods in Biomedical Engineering
|July 23, 2013
PubMed
Summary

This study models myocardial tissue dispersion, revealing its impact on heart deformation and stress. Pathological fiber dispersion significantly alters cardiac function, particularly in diseased hearts.

Keywords:
computational biomechanicsdispersionelectromechanical couplingmyocardium

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Area of Science:

  • Biomedical Engineering
  • Computational Biology
  • Cardiovascular Mechanics

Background:

  • The passive behavior of myocardial tissue is complex, influenced by the intricate arrangement of cardiac muscle fibers and sheets.
  • Existing constitutive models often simplify or neglect the dispersion of these structural orientations, limiting their predictive accuracy.

Purpose of the Study:

  • To develop and validate a computational model that incorporates fiber and sheet dispersion in myocardial tissue.
  • To investigate the influence of varying degrees of dispersion on myocardial deformation, stress development, and overall cardiac function.

Main Methods:

  • Augmenting an existing orthotropic, invariant-based constitutive model with structure parameters to account for fiber and sheet dispersion.
  • Fitting two dispersion parameters to experimentally observed angular dispersion data of myocardial tissue.
  • Performing finite element computations on idealized myocardial tissue cubes, left ventricular slices, and ellipsoidal left ventricle models.

Main Results:

  • The dispersion parameters significantly affect myocardial deformation and stress development.
  • Fiber dispersion in pathological myocardial tissue models demonstrated a substantial impact on cardiac mechanics.
  • While healthy myocardium showed minor pressure-volume loop shifts with dispersion, diseased myocardium exhibited remarkably different behavior.

Conclusions:

  • The developed model effectively captures the influence of fiber and sheet dispersion on myocardial mechanics.
  • Fiber dispersion plays a critical role in the altered mechanics of diseased hearts.
  • This dispersion model holds promise for future simulations of cardiac diseases, including growth and remodeling.