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Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...
Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...

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Related Experiment Video

Updated: May 9, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
05:32

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

Kidney disease and multiple myeloma.

Eliot C Heher1, Helmut G Rennke, Jacob P Laubach

  • 1Nephrology Division and Transplantation Center, Massachusetts General Hospital, Boston, Massachusetts;, †Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, ‡Jerome Lipper Multiple Myeloma Center, Division of Hematologic Malignancy, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts.

Clinical Journal of the American Society of Nephrology : CJASN
|July 23, 2013
PubMed
Summary
This summary is machine-generated.

Multiple myeloma can cause kidney injury, impacting survival. Advances in diagnosing and treating this condition, including novel agents and stem cell transplantation, are improving patient outcomes.

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Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
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Published on: May 1, 2015

Area of Science:

  • Nephrology
  • Hematology
  • Oncology

Background:

  • Kidney injury is a frequent and serious complication in multiple myeloma and other plasma cell dyscrasias, significantly increasing mortality.
  • Pathogenic mechanisms include nephrotoxic monoclonal immunoglobulins (Ig) and other factors independent of paraprotein deposition.
  • Understanding paraprotein-related kidney disease is advancing.

Purpose of the Study:

  • To review the mechanisms of kidney injury in multiple myeloma.
  • To highlight advancements in diagnosis and treatment of myeloma-related kidney disease.
  • To discuss the evolving role of novel therapies and transplantation.

Main Methods:

  • Review of current literature on multiple myeloma and kidney injury.
  • Analysis of diagnostic advancements, including serum free light chain assays.
  • Evaluation of therapeutic strategies, including novel agents, stem cell transplantation, plasma exchange, and kidney transplantation.

Main Results:

  • Serum free light chain quantification aids in early diagnosis and relapse detection.
  • Novel myeloma therapies show promise in reversing renal failure and improving outcomes.
  • Stem cell transplantation is a key treatment for eligible younger patients.

Conclusions:

  • Kidney injury in multiple myeloma has complex causes, with improving diagnostic and therapeutic options.
  • Early detection and novel treatments offer hope for better renal outcomes in multiple myeloma patients.
  • The management landscape for myeloma-related kidney disease is dynamic, with ongoing evolution in treatment strategies.