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Protocol of an observational study to evaluate diabetic nephropathy through detection of microalbuminuria in Indian

Gokulnath1, Manisha Sahay, Sanjay Kalra

  • 1Department of Nephrology, St. Johns Medical College Hospital, Bangalore, India.

Indian Journal of Endocrinology and Metabolism
|July 23, 2013
PubMed
Abstract

Insights

Persistent microalbuminuria (MAU) screening in Indian type 2 diabetes patients using dipstick tests is a reliable method for early diabetic nephropathy detection. This approach can improve healthcare-seeking behaviors and inform treatment strategies.

Area of Science:

  • Nephrology
  • Endocrinology
  • Public Health

Background:

  • Type 2 diabetes mellitus (T2DM) is a growing concern in India.
  • Diabetic nephropathy (DN) is a major complication of T2DM, leading to significant morbidity and mortality.
  • Early detection of DN is crucial for effective management and prevention of kidney disease progression.

Purpose of the Study:

  • To determine the prevalence of persistent microalbuminuria (MAU) in adult Indian patients with T2DM.
  • To evaluate the clinical correlates of MAU detected by dipstick.
  • To assess the predictive value of MAU for kidney disease and its role in prompting healthcare-seeking behavior.

Main Methods:

  • A multicentric, cross-sectional study involving approximately 400,000 patients with T2DM.
  • Screening for MAU using urine dipstick tests on random urine specimens over three visits within 180 days.
  • Correlation of MAU with random blood glucose, height, weight, waist circumference, and blood pressure.

Main Results:

  • The study aims to establish the prevalence of MAU in this population.
  • Clinical correlates and predictive value for kidney disease will be analyzed.
  • The utility of MAU as a cue for healthcare-seeking behavior will be investigated.

Conclusions:

  • Dipstick detection of MAU is a rapid and reliable method for early identification of diabetic nephropathy.
  • Early detection facilitates timely treatment planning and potentially improves patient outcomes.
  • MAU screening can highlight disease burden and encourage proactive healthcare engagement.
Keywords:
Diabetic nephropathyIndiadipstick testhealth policymicroalbuminuria

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