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Updated: May 9, 2026
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Epidemiology and risk factors for chronic kidney disease in patients with ischaemic stroke
Yu-Shi Bao1, Li-Ting Song, Di Zhong
1Department of Nephrology, The First Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, China.
Insights
Patients with ischemic stroke have a high risk of chronic kidney disease (CKD). Key risk factors for CKD in these patients include diabetes, hypertension, and high LDL cholesterol, necessitating aggressive management and public awareness.
Area of Science:
- Nephrology
- Neurology
- Cardiovascular Medicine
Background:
- Chronic kidney disease (CKD) is increasingly linked to cerebrovascular events due to shared risk factors.
- Understanding CKD prevalence and risk factors in ischemic stroke patients is crucial for preventative strategies.
Purpose of the Study:
- To investigate the epidemiology of CKD.
- To characterize the risk factors for CKD within the population experiencing ischemic stroke.
Main Methods:
- Retrospective analysis of 571 ischemic stroke patients.
- Estimated glomerular filtration rate (eGFR) calculated using the MDRD study equation.
- Renal function classified per K/DOQI-CKD guidelines.
Main Results:
- Major CKD risk factors identified: age, diabetes mellitus, hypertension, systolic blood pressure, LDL cholesterol, and serum uric acid.
- Independent risk factors for CKD in ischemic stroke patients included diabetes mellitus (OR 4.146), hypertension with diabetes (OR 3.574), serum uric acid (OR 1.010), and LDL cholesterol (OR 1.431).
Conclusions:
- Ischemic stroke patients represent a high-risk group for CKD, requiring proactive management for prevention.
- The significant prevalence of CKD in this population underscores the need for increased public awareness regarding CKD risks.
Background:
There is growing evidence for an association between chronic renal disease (CKD) and adverse cerebrovascular events because of the overlap of several risk factors. The purpose of this study is to examine the epidemiology of CKD and the characteristics of risk factors for CKD in the population with ischaemic stroke.
Methods:
This retrospective study included 571 patients with ischaemic stroke. Estimated glomerular filtration rate (eGFR) was calculated by the Modification of Diet in Renal Disease (MDRD) study equation. Renal function was assessed according to the Kidney Disease Outcomes Quality Initiative (K/DOQI)-CKD classification.
Results:
Study demonstrated that the major factors associated with CKD in the ischaemic stroke patients were age, diabetes mellitus, hypertension, systolic blood pressure, LDL cholesterol and serum uric acid. Diabetes mellitus (OR 4·146, 95% CI 1·047-16·418, P = 0·043), hypertension and diabetes mellitus (OR 3·574, 95% CI 1·248-10·234, P = 0·018), serum uric acid (OR 1·010, 95% CI 1·006-1·013, P < 0·001) and LDL cholesterol (OR 1·431, 95% CI 1·063-1·928, P = 0·018) were independent risk factors associated with CKD in the patients with ischaemic stroke.
Conclusions:
The patients with ischaemic stroke may be considered as a high-risk population for CKD and be aggressively managed for CKD prevention. The high prevalence of CKD in population with ischaemic stroke prompts the need for greater public awareness about risks of CKD.
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