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Updated: May 9, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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[Antibiotic profylaxis in obstetrics].

E Menzlová1, J Záhumenský, E Kučera

  • 1Gynekologicko-porodnická klinika FNKV a 3. LF UK, Praha. jozef.zahumensky@gmail.com

Ceska Gynekologie
|July 23, 2013
PubMed
Summary
This summary is machine-generated.

Antibiotic prophylaxis effectively reduces surgical site infections after cesarean sections and other obstetric procedures. However, its benefit is unproven for certain interventions and not recommended for spontaneous preterm labor without ruptured membranes.

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Area of Science:

  • Obstetrics and Gynecology
  • Infectious Disease Prevention
  • Surgical Site Infection Control

Background:

  • Nosocomial infections pose significant risks and increase healthcare costs for hospitalized patients.
  • Surgical procedures compromise immunological integrity, elevating the risk of surgical site infections (SSIs).

Purpose of the Study:

  • To review the efficacy of antibiotic prophylaxis in reducing postoperative infectious complications in obstetric and gynecologic procedures.
  • To identify procedures where antibiotic prophylaxis is beneficial, not indicated, or potentially harmful.

Main Methods:

  • Review of recent clinical trials and studies on antibiotic and antiviral prophylaxis in obstetric and gynecologic care.
  • Analysis of evidence supporting or refuting the use of prophylactic antimicrobials in various obstetric interventions.

Main Results:

  • Antibiotic prophylaxis is effective in reducing SSIs for cesarean sections, pregnancy terminations, and extensive perineal repairs.
  • Prophylaxis benefits are not established for amniocentesis, cerclage, or manual uterine evacuation.
  • Routine antibiotic use is not advised in spontaneous preterm labor without membrane rupture due to potential adverse child outcomes.

Conclusions:

  • Antibiotic prophylaxis is a valuable tool for specific obstetric procedures, significantly reducing infection risks.
  • Careful consideration of evidence is crucial to guide appropriate antimicrobial use, avoiding unnecessary administration.
  • Antiviral prophylaxis and specific antimicrobial considerations for obese women and penicillin-allergic patients warrant further attention.