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Published on: February 14, 2021
Diagnostic significance of a mild decrease of baroreflex sensitivity with respect to heart rate in type 1 diabetes
J Svačinová1, N Honzíková, A Krtička
1Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic. 223213@mail.muni.cz.
Physiological Research
|July 23, 2013
Summary
Early autonomic dysfunction in type-1 diabetes mellitus is indicated by decreased baroreflex sensitivity (BRS). This study found BRS is partially dependent on heart rate, suggesting BRSf improves early diagnosis of autonomic dysfunction.
Area of Science:
- Cardiovascular Physiology
- Autonomic Nervous System Function
- Diabetes Mellitus Research
Background:
- Decreased baroreflex sensitivity (BRS) is an early indicator of autonomic dysfunction in type-1 diabetes mellitus.
- Autonomic dysfunction can precede clinical symptoms in diabetic patients.
- Understanding BRS repeatability is crucial for early detection.
Purpose of the Study:
- To evaluate the repeatability of mild baroreflex sensitivity (BRS) decrease in young type-1 diabetics.
- To assess the relationship between BRS, inter-beat interval (IBI), and heart rate variability.
- To determine the diagnostic value of BRSf in early autonomic dysfunction.
Main Methods:
- Continuous finger blood pressure recording in 14 young diabetics and 14 controls for 42 minutes.
- Analysis of 3-minute segments to determine inter-beat interval (IBI), baroreflex sensitivity (BRS), and BRSf.
- Calculation of repeatability coefficients for measured parameters.
Main Results:
- Diabetics showed decreased mean BRS (p=0.05) and a tendency towards shortened IBI (p=0.08) compared to controls.
- BRS was found to be partially dependent on mean IBI in diabetics (p=0.03).
- BRSf demonstrated IBI independence, suggesting its utility in specific diagnostic contexts.
Conclusions:
- Baroreflex sensitivity (BRS) is influenced by mean inter-beat interval (IBI), reflecting both baroreflex impairment and altered cardiac autonomic control.
- The BRSf index offers improved diagnostic value for detecting early autonomic dysfunction in type-1 diabetes.
- Examination of BRSf is highly recommended for early diagnosis and management of diabetic autonomic neuropathy.
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