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Related Experiment Video

Updated: May 9, 2026

Preoxygenation Techniques for Tracheal Intubation in Critically Ill Adults Utilizing Oxygen Mask and Noninvasive Ventilation

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Published on: December 5, 2025

Leaks can dramatically decrease FiO2 on home ventilators: a bench study.

Philippe Goutorbe¹, Erwan Daranda, Yves Asencio

¹Emergency, Anesthesia and ICU Departement, Military Teaching Hospital Sainte Anne, Boulevard Sainte Anne, Toulon 83000, France. goutorbephil@live.fr

BMC Research Notes

|July 23, 2013

Summary

This summary is machine-generated.

Leakage in home ventilators significantly reduces the delivered oxygen concentration (FiO2) for patients with chronic obstructive pulmonary disease (COPD). This can make non-invasive ventilation (NIV) less effective, highlighting the need for better oxygen regulation in home care devices.

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Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)

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Published on: April 7, 2021

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Last Updated: May 9, 2026

Preoxygenation Techniques for Tracheal Intubation in Critically Ill Adults Utilizing Oxygen Mask and Noninvasive Ventilation

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Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)

Published on: April 7, 2021

Area of Science:

Respiratory Medicine
Biomedical Engineering

Background:

Long-term oxygen therapy is vital for hypoxemic COPD patients.
Home-based non-invasive ventilation (NIV) carries risks due to potential leaks.
Delivered fraction of inspired oxygen (FiO2) can be compromised by ventilator leaks.

Purpose of the Study:

To quantify the impact of varying oxygen supply and leak levels on FiO2 delivery.
To assess the performance of the Legendair® home care ventilator under simulated leak conditions.

Main Methods:

A bench study was conducted using four Legendair® ventilators.
Measurements were taken with zero, 5 L/min, and 10 L/min leakage rates.
Oxygen flow rates varied from 1 to 8 L/min.

Main Results:

A 5 L/min leak significantly reduced FiO2 across all tested oxygen flow rates.
A 10 L/min leak substantially decreased FiO2 at 4 and 8 L/min oxygen flows.
Leakage critically impacts the effectiveness of oxygen delivery in home ventilation.

Conclusions:

Ventilator leaks during NIV for COPD can drastically lower inspired FiO2.
Accurate knowledge of dispensed FiO2 is crucial for effective home NIV in COPD.
Industry should develop methods for regulating FiO2 in home care devices.