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Related Concept Videos

Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...

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Related Experiment Video

Updated: May 9, 2026

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images
08:39

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images

Published on: November 20, 2015

Cerebral amyloid angiopathy causing cortical microinfarction.

W Vallat1, A Maundrell, J Leyden

  • 1Lyell McEwin Hospital, Haydown Road, Elizabeth Vale, Adelaide, SA 5112, Australia.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|July 23, 2013
PubMed
Summary

Cerebral amyloid angiopathy is an under-recognized cause of recurrent small strokes. Diagnosis requires specific MRI, and antiplatelet therapy poses risks.

Keywords:
Amyloid angiopathyCortical microinfarctionGradient recalled echoSusceptilbility weighted imaging

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Area of Science:

  • Neurology
  • Neuroradiology

Background:

  • Cerebral amyloid angiopathy (CAA) is a common cause of lobar intracerebral hemorrhage.
  • Its role in recurrent small cortical strokes is often overlooked.

Observation:

  • Patients with recurrent small cortical strokes may have undiagnosed CAA.
  • Haemosiderin-sensitive MRI sequences are crucial for detecting microhemorrhages indicative of CAA.

Findings:

  • Cerebral amyloid angiopathy is an under-recognized cause of recurrent small cortical strokes.
  • Specific MRI techniques are necessary for accurate diagnosis.

Implications:

  • Early diagnosis of CAA can prevent misdiagnosis and inappropriate treatment.
  • Avoiding intensive antiplatelet therapy in these patients is critical to prevent further hemorrhagic complications.