Related Experiment Video
Updated: May 9, 2026

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
Published on: August 23, 2019
XRCC1 polymorphisms and differentiated thyroid carcinoma risk: a meta-analysis
Zhen Hu1, Xueying Hu, Jianxiong Long
1School of Public Health, Guangxi Medical University, 22 Shuangyong Road, Nanning, People's Republic of China.
Abstract:
The objective of this study is to quantitatively derive a more precise estimation of the association between X-ray repair cross-complementing group 1 (XRCC1) gene polymorphisms and differentiated thyroid carcinoma risk. A comprehensive literature search of three databases was conducted. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated with fixed-effect models and random-effect models when appropriate. Overall, no association of the XRCC1 Arg399Gln, Arg280His, and Arg194Trp polymorphisms with differentiated thyroid carcinoma risk was found. In subgroup analyses, a decreased differentiated thyroid carcinoma risk was observed among Caucasians (Gln vs. Arg, OR=0.86, 95% CI=0.77-0.96, P=0.343 for heterogeneity; Gln/Arg vs. Arg/Arg, OR=0.84, 95% CI=0.71-0.98, P=0.229 for heterogeneity; Gln/Gln vs. Arg/Arg, OR=0.77, 95% CI=0.60-0.99, P=0.477 for heterogeneity; dominant genetic model, OR=0.82, 95% CI=0.71-0.95, P=0.272 for heterogeneity), not among Asians. No publication bias was observed. Our results suggest that XRCC1 Arg399Gln polymorphism is not associated with differentiated thyroid carcinoma risk, while a decreased risk is observed among Caucasian population.
Related Concept Videos
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Graves' Disease I: Introduction
Hyperthyroidism II: Pathophysiology
The Ras Gene
Ras is a superfamily...
Synthesis and Regulation of Thyroid Hormones
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
