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Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.

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Correction: The potent human CAR activator CITCO is a non-genotoxic hepatic tumour-promoting agent in humanised constitutive androstane receptor mice but not in wild-type animals.

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Letter to the editor regarding the review article: Yamada T, Cohen SM, Lake BG. The modes of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR) and the peroxisome proliferator-activated receptor alpha (PPARα) are not relevant to human cancer risk: an updated critical evaluation. Crit Rev Toxicol. 2025;55(5):549-586. doi: 10.1080/10408444.2025.2513332.

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Related Experiment Video

Updated: May 9, 2026

Generation of Genetically Modified Mice through the Microinjection of Oocytes
10:19

Generation of Genetically Modified Mice through the Microinjection of Oocytes

Published on: June 15, 2017

Generation and utility of genetically humanized mouse models.

Nico Scheer1, Mike Snaith, C Roland Wolf

  • 1TaconicArtemis, Neurather Ring 1, Koeln 51063, Germany.

Drug Discovery Today
|July 23, 2013
PubMed
Summary

Genetically humanized mouse models, created by introducing human genes into mice, offer superior prediction of human responses. These advanced models enhance translational research for drug discovery and toxicity studies.

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Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells
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Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells

Published on: August 29, 2016

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Last Updated: May 9, 2026

Generation of Genetically Modified Mice through the Microinjection of Oocytes
10:19

Generation of Genetically Modified Mice through the Microinjection of Oocytes

Published on: June 15, 2017

Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells
11:44

Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells

Published on: August 29, 2016

Area of Science:

  • Biomedical research
  • Genetics
  • Pharmacology

Background:

  • Challenges in predicting human responses using traditional animal models due to species divergence.
  • Increasing use of genetic engineering to create more accurate in vivo models.

Purpose of the Study:

  • To review the current state of genetically humanized mouse models.
  • To outline their applications in research, drug discovery, and toxicity assessment.
  • To explore future directions for translational research.

Main Methods:

  • Review of existing literature on genetically humanized mouse models.
  • Description of techniques for generating humanized mouse models.
  • Analysis of applications in various research fields.

Main Results:

  • Genetically humanized mice provide improved predictive value for human responses compared to traditional models.
  • These models are applicable in basic research, drug discovery and development, and clinical drug toxicity studies.
  • Current limitations and future potential of humanized mouse models are discussed.

Conclusions:

  • Genetically humanized mouse models represent a significant advancement in translational research.
  • Further development holds promise for more accurate drug development and toxicity prediction.
  • These models are crucial for bridging the gap between preclinical studies and human clinical outcomes.