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Next-generation Sequencing

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.

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Related Experiment Video

Updated: May 9, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

Lessons from next-generation sequencing analysis in hematological malignancies.

E Braggio¹, J B Egan, R Fonseca

¹Mayo Clinic in Arizona, 13400 East Shea Boulevard, Scottsdale, AZ, USA.

Blood Cancer Journal

|July 23, 2013

Summary

This summary is machine-generated.

Next-generation sequencing advances hematological malignancy research, improving diagnosis and treatment. This technology is transitioning to routine clinical use for personalized medicine strategies.

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Last Updated: May 9, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

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Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

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Published on: April 11, 2016

Area of Science:

Genomics
Hematology
Oncology

Background:

Next-generation sequencing (NGS) has revolutionized hematological malignancy research.
Significant discoveries have been made in diagnosis, risk stratification, clonal evolution, and therapy.

Purpose of the Study:

To review recent advances in understanding hematological malignancies using genome-wide sequencing.
To highlight the transition of sequencing analysis to routine clinical testing and personalized medicine.

Main Methods:

Genome-wide sequence analysis.
Review of recent publications and discoveries in hematological malignancies.

Main Results:

NGS has led to substantial discoveries in hematological malignancies.
Sequencing analysis is becoming integral to clinical testing and individualized medicine.

Conclusions:

Genome-wide sequencing analysis is transforming the study and treatment of blood cancers.
The future involves integrating sequencing data into clinical practice for personalized therapeutic interventions.