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Related Concept Videos

Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Issues And Trends In Healthcare Delivery System01:29

Issues And Trends In Healthcare Delivery System

The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...

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Updated: May 9, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

Educational challenges in implementing genomic medicine.

E Passamani1

  • 1Division of Policy, Communications, and Education, National Human Genome Research Institute, Bethesda, Maryland, USA. eugene.passamani@nih.gov

Clinical Pharmacology and Therapeutics
|July 23, 2013
PubMed
Summary
This summary is machine-generated.

Genomic science is revolutionizing clinical medicine, requiring healthcare professionals to adapt diagnostic and therapeutic strategies. Ongoing education is crucial for medical schools and societies to prevent errors and ensure successful integration of genomics.

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Area of Science:

  • Genomic science
  • Clinical medicine
  • Healthcare innovation

Background:

  • Genomic science advances are driving unprecedented innovation in clinical medicine.
  • The healthcare workforce faces significant upcoming changes in diagnostic and therapeutic approaches.

Purpose of the Study:

  • To highlight the transformative impact of genomics on clinical medicine.
  • To emphasize the need for workforce adaptation and education in response to genomic advancements.

Main Methods:

  • Analysis of current trends in genomic science.
  • Assessment of the impact on clinical practice and healthcare professionals.

Main Results:

  • Genomics necessitates substantial changes in diagnostic and therapeutic strategies.
  • Healthcare professionals will require new skills and knowledge to implement genomic medicine.

Conclusions:

  • Sustained educational efforts are essential for medical schools, training programs, and professional societies.
  • Proactive workforce education is critical to prevent errors and facilitate the integration of genomics into clinical practice.