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Oxidant and antioxidant status in children with subacute sclerosing panencephalitis
Hüseyin Caksen1, Mustafa Ozkan2, Mustafa Cemek3
1Meram Medical Faculty, Department of Pediatrics, Divisions of Pediatric Neurology and Pediatric Genetics, Necmettin Erbakan University, Meram, Konya, Turkey huseyincaksen@hotmail.com.
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Subacute sclerosing panencephalitis (SSPE) patients show increased oxidative damage, indicated by higher malondialdehyde levels. Antioxidant levels were decreased, suggesting the body
Area of Science:
- Neurology
- Biochemistry
- Oxidative Stress Research
Background:
- Subacute sclerosing panencephalitis (SSPE) is a severe, progressive neurological disorder.
- Oxidative stress plays a role in the pathogenesis of various neurological diseases.
Purpose of the Study:
- To evaluate the oxidant and antioxidant status in patients with SSPE.
- To investigate the relationship between oxidative stress markers and disease severity.
Main Methods:
- Analysis of serum and cerebrospinal fluid (CSF) levels of antioxidants (alpha-tocopherol, beta-carotene, retinol, ascorbic acid) and oxidative stress markers (malondialdehyde, reduced glutathione).
- Comparison of these levels between SSPE patients and controls (implied).
- Correlation analysis between marker levels and clinical stages of SSPE.
Main Results:
- Decreased levels of serum antioxidants and erythrocyte/CSF reduced glutathione in SSPE patients.
- Increased levels of erythrocyte and CSF malondialdehyde in SSPE patients.
- CSF malondialdehyde levels correlated positively with SSPE clinical stage severity.
Conclusions:
- SSPE is associated with significant oxidative damage.
- Elevated malondialdehyde indicates lipid peroxidation and cellular damage in SSPE.
- Decreased antioxidant levels may impair the body's defense against oxidative stress in SSPE.
Abstract:
We analyzed serum alpha-tocopherol, beta-carotene, retinol, and ascorbic acid levels and malondialdehyde and reduced glutathione concentrations on erythrocyte and cerebrospinal fluid in 30 patients with subacute sclerosing panencephalitis to evaluate oxidant and antioxidant status. Serum alpha-tocopherol, beta-carotene, retinol, ascorbic acid levels, and erythrocyte and cerebrospinal fluid reduced glutathione concentrations were decreased; however, erythrocyte and cerebrospinal fluid malondialdehyde levels were increased in the patients. Cerebrospinal fluid malondialdehyde levels were different between clinical stages of the disease (P < .05). Higher cerebrospinal fluid malondialdehyde level was associated with the more severe clinical stage. A positive correlation was found between cerebrospinal fluid malondialdehyde level and clinical stages (r = 0.42; P < .05) and between erythrocyte malondialdehyde level and clinical stages (r = 0.40; P < .05). Our findings showed presence of oxidative damage in subacute sclerosing panencephalitis and that antioxidants were increased as defense mechanisms of the organism against oxidative damage.
