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Related Experiment Video

Updated: May 9, 2026

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

Pendrin expression in nodular and non-nodular thyroid tissues.

Berna Temel¹, Nurdan Gul, Faruk Kutluturk

¹Department of Endocrinology and Metabolism, Istanbul University, Faculty of Medicine, Istanbul, Turkey.

Endokrynologia Polska

|July 23, 2013

Summary

Pendrin, an apical iodide transporter, shows altered expression in thyroid nodules. Its expression level does not appear to influence nodule function or be affected by TSH within the nodules.

Related Experiment Videos

Last Updated: May 9, 2026

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

Area of Science:

Endocrinology
Molecular Biology
Thyroid Research

Background:

Pendrin, an apical iodide transporter, exhibits differential expression in nodular thyroid tissues compared to normal thyroid.
Understanding pendrin's role in thyroid nodule function is crucial for diagnosing and managing thyroid conditions.

Purpose of the Study:

To investigate alterations in pendrin expression within thyroid nodules and surrounding non-nodular tissues.
To elucidate the role of pendrin in the functional characteristics of thyroid nodules.

Main Methods:

Comparative analysis of pendrin expression (mRNA and protein) in 26 nodular and paired non-nodular thyroid tissues.
Categorization of nodules into 'hot' (n=18) and 'cold' (n=8) based on functional activity.
Quantitative RT-PCR and immunohistochemical analysis were employed.

Main Results:

Pendrin protein expression was significantly elevated in both hot and cold nodules compared to adjacent normal thyroid tissue.
While mRNA levels were comparable in hot nodules, cold nodules showed significantly decreased pendrin mRNA levels relative to normal tissue.
No significant difference in pendrin expression was observed between hot and cold nodules.

Conclusions:

Thyroid nodule pendrin expression is not influenced by TSH levels within the nodules.
The level of pendrin expression does not seem to directly impact the functional status (hot or cold) of thyroid nodules.