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Cardiovascular magnetic resonance characteristics in children with hypertrophic cardiomyopathy

Yan Chaowu1, Zhao Shihua, Ling Jian

  • 1Departments of Radiology, Pathology, and Nuclear Medicine, Cardiovascular Institute and Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Circulation. Heart Failure
|July 23, 2013
PubMed

Insights

Cardiovascular magnetic resonance (CMR) reveals that late gadolinium enhancement (LGE) in children with hypertrophic cardiomyopathy (HCM) is similar to adults and predicts adverse events, necessitating further research.

Area of Science:

  • Pediatric Cardiology
  • Cardiovascular Imaging
  • Genetic Heart Diseases

Background:

  • Cardiovascular magnetic resonance (CMR) is crucial for diagnosing and stratifying risk in adult hypertrophic cardiomyopathy (HCM).
  • Limited data exist on CMR findings in pediatric HCM.
  • This study evaluates CMR characteristics in children with idiopathic HCM.

Purpose of the Study:

  • To assess cardiovascular magnetic resonance (CMR) features in children diagnosed with idiopathic hypertrophic cardiomyopathy (HCM).
  • To compare CMR parameters between pediatric HCM patients and healthy children.
  • To investigate the association between CMR findings and adverse clinical outcomes in pediatric HCM.

Main Methods:

  • Cardiovascular magnetic resonance (CMR) was performed on 71 children with idiopathic HCM and compared with 71 healthy controls.
  • Left ventricular (LV) parameters were indexed by body surface area.
  • Late gadolinium enhancement (LGE) prevalence and extent were analyzed.

Main Results:

  • In 71 children with idiopathic HCM, concentric LV hypertrophy was observed in 12.7%, with 2 progressing to end-stage disease.
  • Late gadolinium enhancement (LGE) prevalence was 73%, with an average extent of 10.4% of LV mass.
  • Children with HCM and LGE showed increased LV mass (P=0.025) and LGE extent correlated with adverse events (HR 1.1, P=0.004).

Conclusions:

  • The prevalence and extent of LGE in pediatric HCM are comparable to adult HCM.
  • LGE in children with HCM is associated with a higher risk of adverse events.
  • Larger studies with longer follow-up are needed to confirm these findings in pediatric HCM.
Abstract

Keywords:
cardiomyopathy, hypertrophiccardiovascular magnetic resonancechildren/childhooddeath, sudden, cardiacheart failurelate gadolinium enhancement

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