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Updated: May 9, 2026
Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
Published on: July 28, 2013
Association between structural and functional corticospinal involvement in amyotrophic lateral sclerosis assessed by
Aude-Marie Grapperon1, Annie Verschueren, Yann Duclos
1Department of Neurology and Neuromuscular Diseases, CHU La Timone, 264 rue Saint-Pierre, 13385, Marseille, France.
Introduction:
We investigated the functional and structural integrity of the corticospinal tract (CST) using diffusion tensor imaging (DTI) and the triple stimulation technique (TST) in patients with amyotrophic lateral sclerosis (ALS).
Methods:
Fourteen patients with ALS, 13 healthy controls (HCs), and 6 patients with lower motor neuron (LMN) syndrome underwent DTI and TST.
Results:
The mean diffusivity was higher in ALS patients than HCs (P < 0.01). The TST ratio was lower in ALS patients compared with HCs (P < 0.001) and in LMN patients compared with HCs (P < 0.05). The increase in the mean diffusivity was correlated with the decrease in the TST ratio (P < 0.01).
Conclusions:
Significant correlations exist between the DTI and TST results, indicating both structural and functional involvement of the CST in patients with ALS.
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