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Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
NF-kB-dependent Signaling Pathway02:26

NF-kB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
Regulation of Bacterial Virulence01:28

Regulation of Bacterial Virulence

Pathogenic bacteria employ a range of regulatory mechanisms to modulate the expression of virulence genes in response to environmental and host-derived signals. These mechanisms ensure that virulence factors are expressed only under favorable conditions, thereby optimizing infection and survival strategies.Mechanisms of Virulence RegulationKey regulatory strategies include:Two-Component Systems: These consist of a membrane-bound sensor kinase and a cytoplasmic response regulator. Environmental...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

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NF-&#954;B-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells
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Published on: January 12, 2020

Bacterial interference with canonical NFκB signalling.

Mona Johannessen1, Fatemeh Askarian1, Maria Sangvik1

  • 1Research Group of Host-Microbe Interactions, Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.

Microbiology (Reading, England)
|July 23, 2013
PubMed
Summary
This summary is machine-generated.

Bacteria evade the immune system by interfering with the pattern-recognition receptor (PRR)-NFκB pathway. Understanding these bacterial evasion mechanisms could lead to new anti-inflammatory therapies.

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Area of Science:

  • Immunology
  • Microbiology
  • Molecular Biology

Background:

  • The human immune system combats microbes via pattern-recognition receptors (PRRs) and the NFκB pathway.
  • Activation of PRRs initiates inflammatory responses crucial for pathogen clearance.

Purpose of the Study:

  • To review the PRR-NFκB pathway's role in immunity.
  • To explore bacterial strategies for evading this pathway.
  • To discuss potential therapeutic applications of bacterial evasion molecules.

Main Methods:

  • Literature review of the PRR-NFκB pathway.
  • Analysis of bacterial immune evasion mechanisms.
  • Discussion of potential anti-inflammatory agents derived from bacterial molecules.

Main Results:

  • Bacteria actively disrupt the PRR-NFκB signaling cascade.
  • Evasion strategies include altering bacterial surfaces, producing decoys, and injecting effector proteins.
  • These mechanisms aim to suppress host inflammatory responses.

Conclusions:

  • Bacterial interference with the PRR-NFκB pathway is a significant challenge to host immunity.
  • Bacterial immune evasion molecules represent a promising source for novel anti-inflammatory drugs.