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Disrupted prefrontal interhemispheric structural coupling in schizophrenia related to working memory performance.

Anne L Wheeler1, M Mallar Chakravarty2, Jason P Lerch3

  • 1Kimel Family Translational Imaging Genetics Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada;

Schizophrenia Bulletin
|July 23, 2013
PubMed
Summary

Schizophrenia patients show reduced cortical thickness and impaired structural coupling in prefrontal circuits, impacting working memory. This highlights a potential vulnerability pathway for cognitive deficits in schizophrenia.

Keywords:
MRIcortical thicknessdorsolateral prefrontal cortexstructural coupling

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