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Porphyrin-linked oligonucleotides. Synthesis and sequence-specific modification of ssDNA
E I Frolova1, E M Ivanova, V F Zarytova
1Institute of Bioorganic Chemistry, Siberian Division of the USSR Academy of Sciences, Novosibirsk.
FEBS Letters
|August 20, 1990
Abstract:
Oligonucleotide derivatives bearing hemin and deuterohemin groups were synthesized. The derivatives efficiently react with the complementary nucleotide sequence in ssDNA forming covalent adducts and piperidine-labile sites. In the case of the deuterohemin derivative, some direct cleavage of the target DNA occurs.