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Published on: June 11, 2020
Video-EEG recordings in full-term neonates of diabetic mothers: observational study
José Ramón Castro Conde1, Nieves Luisa González González, Desiré González Barrios
1Department of Neonatology, Hospital Universitario de Canarias, , La Laguna, Spain.
Objective:
To determine whether full-term newborn infants of diabetic mothers (IDM) present immature/disorganised EEG patterns in the immediate neonatal period, and whether there was any relationship with maternal glycaemic control.
Design And Setting:
Cohort study with an incidental sample performed in a tertiary hospital neonatal unit.
Patients:
23 IDM and 22 healthy newborns born between 2010 and 2013.
Interventions:
All underwent video-EEG recording lasting >90 min at 48-72 h of life.
Main Outcome Measures:
We analysed the percentage of indeterminate sleep, transient sharp waves per hour and mature-for-gestational age EEG patterns (discontinuity, maximum duration of interburst interval (IBI), asynchrony, asymmetry, δ brushes, encoches frontales and α/θ rolandic activity). The group of IDM was divided into two subgroups according to maternal HbA1c: (1) HbA1c≥6% and (2) HbA1c<6%.
Results:
Compared with healthy newborns, IDM presented significantly higher percentage of indeterminate sleep (57% vs 25%; p<0.001), discontinuity (2.5% vs 0%; p=0.044) and δ brushes in the bursts (6% vs 3%; p=0.024); higher duration of IBI (0.3 s vs 0 s; p=0.017); fewer encoches frontales (7/h vs 35/h; p<0.001), reduced θ/α rolandic activity (3/h vs 9/h; p<0.001); and more transient sharp waves (25/h vs 5/h; p<0.001). IDM with maternal HbA1c≥6% showed greater percentage of δ brushes in the burst (14% vs 4%; p=0.007).
Conclusions:
Full-term IDM newborns showed video-EEG features of abnormal development of brain function. Maternal HbA1c levels<6% during pregnancy could minimise the risk of cerebral dysmaturity.
