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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Forced Transdifferentiation01:28

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial transdifferentiation occurs...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...

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Related Experiment Video

Updated: May 9, 2026

Counting Human Neural Stem Cells
06:37

Counting Human Neural Stem Cells

Published on: August 22, 2007

The stem cell wars: a dispatch from the front.

Allen M Spiegel1

  • 1Albert Einstein College of Medicine, Belfer 312, 1300 Morris Park Avenue, Bronx, NY 10461, USA. allen.spiegel@einstein.yu.edu

Transactions of the American Clinical and Climatological Association
|July 23, 2013
PubMed
Summary
This summary is machine-generated.

Human embryonic stem cell (hESC) research holds promise for treating diseases like diabetes and Parkinson's. Policy debates and funding initiatives impact scientific progress toward regenerative medicine cures.

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Passaging Human Neural Stem Cells
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Last Updated: May 9, 2026

Counting Human Neural Stem Cells
06:37

Counting Human Neural Stem Cells

Published on: August 22, 2007

Passaging Human Neural Stem Cells
10:16

Passaging Human Neural Stem Cells

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Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells
06:32

Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells

Published on: September 1, 2010

Area of Science:

  • Regenerative Medicine
  • Stem Cell Biology
  • Biomedical Research Policy

Background:

  • Human embryonic stem cell (hESC) development in 1998 offered potential for treating intractable diseases.
  • The 2001 policy restricting federal funding for hESC research sparked significant controversy.
  • State-funded initiatives, like the California Institute of Regenerative Medicine (CIRM), emerged in response to federal funding limitations.

Observation:

  • The author provides a first-hand perspective on the legal and science policy debates surrounding hESC research.
  • Observations are informed by leadership roles in NIDDK, NIH Stem Cell Task Force, and advisory positions for CIRM and IOM.

Findings:

  • Selective summary of research progress toward cures for diseases such as type 1 diabetes, Parkinson's disease, and spinal cord injury.
  • Analysis of the impact of policy decisions on the trajectory of stem cell research and regenerative medicine.

Implications:

  • Continued debate and evolving funding landscapes shape the future of stem cell research.
  • Progress in hESC research is crucial for advancing regenerative medicine and developing novel therapies for debilitating conditions.