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[Acid-base homeostasis and the thyro-parathyroid glands]
Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences. Serie D: Sciences Naturelles
|May 12, 1975
Summary
Parathyroid glands play a crucial role in maintaining blood pH homeostasis by facilitating bicarbonate supply from bone, independent of bone resorption. Chronic acidosis severely impacts parathyroidectomized rats.
Area of Science:
- Endocrinology
- Bone Metabolism
- Acid-Base Balance
Context:
- Chronic metabolic acidosis is linked to hyperparathyroidism and bone disease.
- The specific role of thyroparathyroid glands in acidosis-induced bone lesions requires elucidation.
Purpose:
- To investigate the effects of an acidic diet on parathyroidectomized (PTX), thyroparathyroidectomized (TPTX), and sham-operated (Sh-O) growing rats.
- To determine the involvement of parathyroid glands in the bone resorption and acid-base balance during chronic acidosis.
Summary:
- Acidic diet induced increased urinary calcium, phosphate, and acidity in all groups.
- Parathyroidectomy exacerbated bone resorption markers (hydroxyproline, 85-sr excretion) and worsened acidosis in PTX and TPTX rats.
- Parathyroid glands contribute to extracellular fluid defense against acidosis via a non-bone resorptive mechanism, potentially supplying bicarbonates for pH homeostasis.
Impact:
- Highlights the critical role of parathyroid glands in maintaining acid-base balance.
- Suggests a novel, non-resorptive mechanism for parathyroid involvement in pH homeostasis.
- Provides insights into the pathogenesis of bone lesions in chronic metabolic acidosis.