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Small bowel enema in non-responsive coeliac disease
1Alistair Frazer and John Squire Clinical Investigation Unit, Birmingham.
Gut
|August 1, 1990
Summary
Radiological imaging revealed a distinct jejunoileal fold pattern in non-responsive coeliac disease patients. This pattern, characterized by reduced jejunal folds and increased ileal folds, aids in identifying patients at risk of complications.
Area of Science:
- Gastroenterology
- Radiology
- Immunology
Background:
- Coeliac disease is an autoimmune disorder triggered by gluten ingestion.
- Non-responsive coeliac disease (NRCD) presents diagnostic challenges and increased complication risks.
- Radiological markers for NRCD require further elucidation.
Purpose of the Study:
- To identify specific radiological features differentiating non-responsive coeliac disease from other states.
- To assess the diagnostic utility of small bowel enema findings in coeliac disease management.
Main Methods:
- Small bowel enema performed on four groups: NRCD patients, untreated coeliac patients, gluten-free diet responders, and healthy controls.
- Radiological assessment focused on jejunal and ileal fold patterns.
Main Results:
- A reversed jejunoileal fold pattern (reduced jejunal folds, increased ileal folds) was observed in 8/9 NRCD patients.
- This pattern was present in 1/7 untreated coeliac patients, but absent in responders and controls.
- The identified pattern is a significant radiological marker for NRCD.
Conclusions:
- The reversed jejunoileal fold pattern is a specific radiological finding in non-responsive coeliac disease.
- This radiological marker can help identify coeliac patients with poor treatment response and high complication risk.
- Small bowel enema may serve as a valuable tool in assessing coeliac disease non-responsiveness.