[Management of the carotid artery stenosis]
Sébastien Déglise1, Céline Dubuis, Pascal Mosimann
1Service de Chirurgie Thoracique et Vasculaire Division de Chirurgie Vasculaire, CHUV, Lausanne. sebastien.deglise@chuv.ch
Insights
Carotid artery stenosis is a leading cause of stroke in older adults. Treatment options include surgery and stenting, with best medical treatment reducing stroke rates and limiting interventions.
Area of Science:
- Vascular Surgery
- Neurology
- Cardiology
Context:
- Carotid artery stenosis is a significant risk factor for ischemic stroke, particularly in elderly populations.
- Symptomatic stenosis exceeding 50% within two weeks necessitates therapeutic intervention.
- Advances in medical treatment have altered the landscape of managing carotid stenosis.
Purpose:
- To review the therapeutic indications and treatment options for carotid artery stenosis.
- To compare the efficacy and risks of carotid endarterectomy versus carotid stenting.
- To highlight the role of best medical treatment in managing carotid stenosis and preventing stroke.
Summary:
- Carotid endarterectomy is the preferred surgical approach for symptomatic stenosis (>50%), offering superior outcomes compared to stenting in most patients.
- Carotid stenting is a viable alternative for patients at high surgical risk, despite a higher post-operative stroke and death rate.
- Comprehensive medical management, including risk factor modification, statins, and antiplatelet therapy, has drastically reduced stroke incidence.
- Intervention for asymptomatic stenosis is now limited to specific high-risk individuals (e.g., men with >70% stenosis and 5-year life expectancy).
Impact:
- Optimized treatment strategies for carotid artery stenosis can significantly reduce the incidence of ischemic stroke.
- Risk stratification is crucial for selecting the most appropriate intervention (surgery, stenting, or medical management).
- The evolution of medical therapy has decreased the need for invasive procedures in certain patient groups, improving overall patient outcomes.
Abstract:
In the western world, the carotid-artery stenosis is one of the major causes of ischemic stroke in elderly people. The principal therapeutic indication is a symptomatic stenosis > 50% in the first two weeks and the surgical approach has shown the best results. Despite inferior results to carotid endarterectomy in terms of post-operative rate of stroke and/or death, except for young patients, carotid stenting remains the best choice in patients at high surgical risk. The best medical treatment, consisting in correction of cardiovascular risk factors, statin therapy and anti-aggregation led to a drastic reduction in the annual rate of stroke associated to carotid stenosis and thus limited the surgical intervention in asymptomatic patient to men with a life expectancy of at least 5 years and a stenosis > 70%.
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