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Nondisjunction

Nondisjunction

Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers. Nondisjunction is common during anaphase I or anaphase II of meiosis. Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...

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Related Experiment Video

Updated: Mar 3, 2026

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

Non-invasive prenatal aneuploidy testing: technologies and clinical implication

Brynn Levy¹, Errol Norwitz

¹Department of Pathology and Cell Biology, College of Physicians and Surgeons of Physicians and Surgeons of Columbia University, NY, USA.

MLO: Medical Laboratory Observer

|July 24, 2013

Summary

No abstract available in PubMed .

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