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Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

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Related Experiment Video

Updated: May 9, 2026

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors

Published on: July 8, 2012

Hormonal control of stem cell systems.

Dana Gancz¹, Lilach Gilboa

¹Department of Biological Regulation, Weizmann Institute of Science, Rehovot, 76100 Israel; email: dana.gancz@weizmann.ac.il , lilach.gilboa@weizmann.ac.il.

Annual Review of Cell and Developmental Biology

|July 24, 2013

Summary

This summary is machine-generated.

Hormones profoundly influence stem cell biology across multiple organs, regulating their entire life cycle. This hormonal control is crucial for coordinating the body's adaptation to physiological changes.

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Stromal Cell Isolation From Hematopoietic Organs

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Published on: January 26, 2024

Area of Science:

Endocrinology
Stem Cell Biology
Physiology

Background:

Organs adapt to physiological challenges by altering tissue size and composition.
Tissue-specific stem cells and their niches are central to these adaptive changes.
The endocrine system plays a key role in mediating physiological adaptations.

Purpose of the Study:

To review the multifaceted effects of hormones on stem cell biology.
To explore hormone-stem cell interactions in the ovary, intestine, hematopoietic system, and mammary gland.
To understand how hormones coordinate the body's response to physiological challenges via stem cells.

Main Methods:

Literature review focusing on hormonal regulation of stem cells.
Analysis of stem cell behavior in four distinct organ systems.
Examination of cell-autonomous and non-cell-autonomous hormonal effects.

Main Results:

Hormones impact all phases of stem cell life: establishment, expansion, maintenance, and differentiation.
Hormonal effects can be direct (cell-autonomous) or indirect via the stem cell niche (non-cell-autonomous).
A single hormone can elicit diverse responses depending on the stem cell type and developmental stage.

Conclusions:

Hormones are critical regulators of stem cell function across various organs.
The complexity of hormonal signaling allows for precise coordination of physiological responses.
Understanding these interactions is key to comprehending tissue adaptation and homeostasis.